Demographic characteristics and neuropsychological and behavioral performance in overall PDSD cohort and the subset available for inclusion in the imaging analyses: Mean ±SD1, 2
| All PDSD | subset of PDSD with MRI | |
|---|---|---|
| M/F | 18/5 | 9/2 |
| Education (y) | 16.4 ±2.1 | 16.4 ±2.2 |
| Age of onset (y) | 60.4 ±8.5 | 60.0 ±7.4 |
| Age at Time 1 (y) | 69.0 ±6.4 | 68.6 ±8.4 |
| Disease duration at Time 1 (y) | 8.5 ±6.0 | 8.5 ±4.5 |
| Time 1 to Time 2 interval (mos) | 37.4 ±23.7 | 39.3 ±24.2 |
| Language measures | ||
| Words per minute, Time 1 | 121 ±35 | 133 ±39 |
| Words per minute, Time 2 | 112 ±42 | 113 ±51 |
| Mean length of utterance, Time 1 | 10.7 ±2.6 | 11.0 ±2.6 |
| Mean length of utterance, Time 2 | 10.3 ±3.2 | 9.8 ±2.6 |
| Report of content (max=9), Time 1 | 6.7 ±1.4 | 6.5 ±1.4 |
| Report of content (max=9), Time 2 | 6.0 ±1.7 | 5.5 ±1.6 |
| Clinical measures | ||
| UPDRS I Motivation / Initiative, Time 1 (max=4) | 0.25 ±0.45 (16) | 0.43 ±0.54 (7) |
| UPDRS I Motivation / Initiative, Time 2 (max=4) | 0.72 ±0.67 (18) | 0.88 ±0.84 (8) |
| UPDRS II: oral motor score, Time 1 (max=12) | 1.63 ±1.63 (16) | 1.71 ±1.25 (7) |
| UPDRS II: oral motor score, Time 2 (max=12) | 2.35 ±2.03 (17) | 2.71 ±1.80 (7) |
| UPDRS III, Time 1 | 24.4 ±11.0 (16) | 18.6 ±7.1 (7) |
| UPDRS III, Time 2 | 33.5 ±15.3 (17) | 30.0 ±14.8 (7) |
| Hoehn & Yahr stage, Time 1 | 2.95 ±0.76 (20) | 3.10 ±0.99 (10) |
| Hoehn & Yahr stage, Time 2 | 3.05 ±0.76 (20) | 3.20 ±0.92 (10) |
| Cognitive measures | ||
| MMSE, Time1 | 27.4 ±2.6 (23) | 27.1 ±2.9 (11) |
| MMSE, Time2 | 25.5 ±4.6 (22) | 25.4 ±4.0 (11) |
| BNT, Time 1 | 27.4 ±3.1 (22) | 28.4 ±2.1 (11) |
| BNT, Time 2 | 26.8 ±4.6 (20) | 27.3 ±4.2 (9) |
| FAS Total, Time 1 | 39.7 ±14.0 (22) | 35.8 ±9.3 (11) |
| FAS Total, Time 2 | 35.2 ±13.8 (18) | 32.9 ±10.4 (8) |
| Reverse digit span, Time 1 | 4.9 ±1.4 (22) | 5.1 ±1.4 (11) |
| Reverse digit span, Time 2 | 4.9 ±1.3 (16) | 3.9 ±1.6 (7) |
1
All comparisons between the full patient cohort and the subset of patients with imaging data are not statistically significant; p>.2 for all comparisons.
2
For neuropsychological and clinical tests, the number of participants with available data for each group is given in parentheses.