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. Author manuscript; available in PMC: 2018 Aug 15.
Published in final edited form as: Int J Cancer. 2017 Jun 1;141(4):721–730. doi: 10.1002/ijc.30785

Figure 2.

Figure 2

The four independent SNPs and melanoma survival. a–d. Kaplan–Meier survival curves of the combined risk genotypes: the exact numbers of unfavorable genotypes (NUGs) (a) in MDACC study and (c) in the Harvard study; dichotomized groups of the NUGs (b) in the MDACC study and (d) in the Harvard study. e–f. Time-dependent area under the curve (AUC) and receiver operating characteristic (ROC) curve estimation for prediction of melanoma-specific survival. (e) Time-dependent AUC estimation, based on age, sex, Breslow thickness, stage, ulceration, mitotic rate and the NUGs in the MDACC study and (f) five-year melanoma-specific survival prediction by ROC curve in the MDACC study.