Table 2.

Associations between the four independent SNPs and the CMSS in the MDACC and Harvard studies

Genotype		MDACC				Harvard
		All	Death (%)	HR (95% CI)a	Pa	All	Death (%)	HR (95% CI)b	Pb
RHOU rs10916352
	GG	231	12 (5.2)	1.00		109	9 (8.3)	1.00
	GC	404	54 (13.4)	2.50 (1.33–4.69)	0.005	195	22 (11.3)	1.40 (0.64–3.06)	0.395
	CC	223	29 (13.0)	2.49 (1.27–4.91)	0.008	105	17 (16.2)	2.22 (0.99–5.01)	0.054
	Trend test				0.012				0.047
	CC+GC	627	83 (13.2)	2.50 (1.36–4.58)	0.003	300	39 (13.0)	1.67 (0.81–3.46)	0.167
ARHGAP22 rs3851552
	TT	361	31 (8.6)	1.00		168	10 (6.0)	1.00
	TC	386	52 (13.5)	1.99 (1.26–3.16)	0.003	190	32 (16.8)	2.85 (1.40–5.81)	0.004
	CC	111	12 (10.8)	1.71 (0.85–3.46)	0.135	51	6 (11.8)	2.18 (0.79–6.02)	0.134
	Trend test				0.016				0.024
	CC+TC	497	64 (12.9)	1.94 (1.24–3.03)	0.004	241	38 (15.8)	2.72 (1.36–5.47)	0.005
ARHGAP44 rs72635537
	CC	725	73 (10.1)	1.00		327	33 (10.1)	1.00
	CT	124	21 (16.9)	2.12 (1.29–3.48)	0.003	78	14 (17.9)	2.06 (1.10–3.86)	0.024
	TT	9	1 (11.1)	2.09 (0.28–15.8)	0.477	4	1 (25.0)	2.54 (0.35–18.59)	0.359
	Trend test				0.004				0.018
	TT+CT	133	22 (16.5)	2.12 (1.29–3.46)	0.003	82	15 (18.3)	2.09 (1.13–3.85)	0.019
ARHGEF10 rs7826362
	AA	409	34 (8.3)	1.00		210	19 (9.0)	1.00
	AT	373	49 (13.1)	1.52 (0.97–2.39)	0.071	158	21 (13.3)	1.65 (0.88–3.07)	0.116
	TT	76	12 (15.8)	2.20 (1.13–4.31)	0.021	41	8 (19.5)	2.46 (1.07–5.65)	0.033
	Trend test				0.012				0.022
	TT+AT	449	61 (13.6)	1.62 (1.05–2.51)	0.029	199	29 (14.6)	1.81 (1.01–3.24)	0.045

Abbreviations: SNP, single nucleotide polymorphism; CMSS, cutaneous melanoma-specific survival; MDACC, The University of Texas M.D. Anderson Cancer Center; HR, hazards ratio; CI, confidence interval.

^aAdjusted for age, gender, Breslow thickness, stage, ulceration, and mitotic rate.

^bAdjusted for age and gender.