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. Author manuscript; available in PMC: 2018 Aug 15.
Published in final edited form as: Int J Cancer. 2017 Jun 1;141(4):731–743. doi: 10.1002/ijc.30787

Table 2.

The 14 SNPs exhibiting differences between two racial groups

SNP Gene Location MEC & Ghana, African PLCO & BPC3, non-Hispanic white Heterogeneity c Meta-regressiond Interactione
Allelea EAF OR (95%CI)b Pb Allelea EAF OR (95%CI)b Pb Q I2 P for the racial group P
6 Top SNPs identified in African Descendants
 rs56197129 TP63 Intron C/A 0.17 1.35 (1.15–1.60) 3.16E-04 C/A 0.12 1.14 (0.97–1.34) 0.110 0.148 52.3 0.148 0.007
 rs6795002 TP63 Intron T/A 0.18 1.35 (1.15–1.59) 2.51E-04 T/A 0.13 1.14 (0.97–1.34) 0.114 0.142 53.6 0.142 0.006
 rs55851920 TP63 Intron T/C 0.17 1.36 (1.15–1.60) 2.77E-04 T/C 0.12 1.15 (0.98–1.35) 0.097 0.152 51.2 0.152 0.011
 rs7616437 TP63 Intron A/G 0.18 1.37 (1.16–1.60) 1.44E-04 A/G 0.19 1.09 (0.87–1.36) 0.461 0.106 61.7 0.080 0.004
 rs722921f ALDH1A1 Intron T/A 0.18 0.73 (0.61–0.88) 0.001 A/T 0.46 1.00 (0.83–1.21) 0.991 0.019 81.7 0.033 0.032
 rs855723 WNT1 5′-Upstream A/G 0.48 1.26 (1.10–1.43) 0.001 A/G 0.15 1.04 (0.90–1.22) 0.589 0.067 70.1 0.067 0.040
8 Top SNPs identified in Non-Hispanic Whites
 rs2072454 EGFR Exon-Synonymous T/C 0.51 0.89 (0.72–1.10) 0.285 T/C 0.48 1.23 (1.10–1.37) 2.66E-04 0.009 85.6 0.012 0.001
 rs2270247 EGFR Intron T/G 0.50 0.89 (0.73–1.10) 0.293 T/G 0.48 1.23 (1.10–1.37) 2.47E-04 0.008 85.6 0.012 0.001
 rs730437 EGFR Intron C/A 0.51 0.89 (0.73–1.10) 0.291 C/A 0.48 1.23 (1.10–1.37) 2.47E-04 0.008 85.7 0.012 0.001
 rs2075109 EGFR Intron C/T 0.45 0.98 (0.86–1.11) 0.755 C/T 0.48 1.23 (1.11–1.37) 1.74E-04 0.007 86.0 0.016 0.024
 rs2075110 EGFR Intron T/C 0.37 0.96 (0.84–1.09) 0.506 T/C 0.48 1.23 (1.11–1.38) 1.69E-04 0.004 88.3 0.008 0.013
 rs6944695 EGFR Intron C/T 0.50 0.93 (0.82–1.06) 0.281 C/T 0.48 1.23 (1.10–1.37) 2.21E-04 0.001 90.4 0.002 0.004
 rs2075111 EGFR Intron G/C 0.50 0.93 (0.82–1.06) 0.264 G/C 0.48 1.23 (1.10–1.37) 2.21E-04 0.001 90.6 0.002 0.003
 rs12718946 EGFR Intron G/C 0.42 0.91 (0.80–1.04) 0.160 G/C 0.48 1.23 (1.10–1.37) 1.86E-04 0.001 91.8 0.001 0.003

Abbreviations: MEC, Multiethnic/Minority Cohort Study of Diet and Cancer; PLCO, Prostate, Lung, Colorectal and Ovarian; BPC3, Breast and Prostate Cancer Cohort Consortium; EAF, effect allele frequency; OR, odds ratio; CI, confidence interval

a

Referring to “reference allele/effect allele”.

b

Meta-analysis of the two studies in each population. Logistic regression analysis was adjusted for age and principal components in each study.

c

Heterogeneity between results from the two racial groups were defined as Q-test P ≤ 0.100 or I2 ≥ 50.0%.

d

Meta-regression analysis of results from the four studies (MEC, Ghana, PLCO and BPC3) as independent datasets included the racial group as a moderator. Results of the four studies were shown in Supporting Information Table 6.

e

The multiplicative interaction of each SNP and racial group in logistic regression analysis was adjusted for age and racial group in a pooled dataset from the four studies with 2,753 cases and 3,666 controls.

f

All four studies used A as the effect allele for rs722921 in analyses of Q-test, I2, meta-regression and multiplicative interaction.