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. 2017 Aug;23(8):1200–1208. doi: 10.1261/rna.058511.116

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© 2017 Lindblad et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article, published in RNA, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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FIGURE 1. — The template model of genome rearrangement. As the parental MAC degrades, (A) bidirectional transcription of the parental chromosomes produces lncRNA copies. In the developing MAC, (B) Otiwi1 (blue circles) associates with 27-nt piRNAs to mark MDSs (numbered) for retention. (C) The lncRNA templates are transported to the developing MAC, where they guide the correct configuration. (D) DNA breaks permit recombination between MDSs, with concomitant loss of MIC-limited DNA (light gray). Telomeres (black bars) cap sequence ends to form a mature MAC chromosome.