Table 3.
Clinical characteristics of patients with acute pancreatitis with or without infectious complications
| Non-IC group (n = 38) | IC group (n = 25) | p Value | |
|---|---|---|---|
| Age, years | 45.34 ± 2.56 | 53.60 ± 2.53 | 0.037 |
| Female/male, n | 14/24 | 8/17 | |
| WBC count, ×109/L | 12.49 ± 0.93 | 13.32 ± 1.06 | 0.559 |
| BUN, mmol/L | 12.71 ± 1.26 | 17.22 ± 2.49 | 0.088 |
| Hematocrit | 0.41 ± 0.01 | 0.42 ± 0.02 | 0.701 |
| APACHE II score | 10 ± 0.68 | 15.12 ± 1.10 | 0.000 |
| Lymphocyte count on day 1, ×109/L | 1.00 ± 0.05 | 0.79 ± 0.05 | 0.012 |
| Lymphocyte count on day 3, ×109/L | 1.08 ± 0.06 | 0.86 ± 0.06 | 0.016 |
| IL-10 concentration on day 1, pg/ml | 30.83 ± 1.56 | 41.86 ± 2.56 | 0.000 |
| IL-10 concentration on day 3, pg/ml | 26.09 ± 1.37 | 32.85 ± 2.24 | 0.017 |
| Percentage of HLA-DR expression on CD14+ monocytes on day 1 | 44.51 ± 2.19 | 36.30 ± 2.99 | 0.027 |
| Percentage of HLA-DR expression on CD14+ monocytes on day 3 | 46.64 ± 2.01 | 37.24 ± 2.86 | 0.010 |
| Percentage of PD-1 expression on CD4+ lymphocytes on day 1, (%) | 33.31 ± 1.40 | 38.83 ± 2.02 | 0.024 |
| Percentage of PD-1 expression on CD4+ lymphocytes on day 3 | 28.98 ± 1.13 | 33.38 ± 1.95 | 0.041 |
| Percentage of PD-L1 expression on CD14+ monocytes on day 1 | 22.96 ± 1.42 | 29.94 ± 2.26 | 0.010 |
| Percentage of PD-L1 expression on CD14+ monocytes on day 3 | 30.00 ± 1.04 | 34.46 ± 1.67 | 0.020 |
| Mortality | 2 (9.09%) | 2 (6.67%) | 1.000 |
Abbreviations: APACHE Acute Physiology and Chronic Health Evaluation, BUN Blood urea nitrogen, IL Interleukin, HLA-DR Human leukocyte antigen-DR, IC Infectious complications, PD-1 Programmed cell death receptor 1, PD-L1 Programmed cell death receptor ligand 1, WBC White blood cell
Data are shown as mean ± SEM