Table 1.
Characteristics of the cohort overall and by four obesity/HIV status categories: non-obese HIV-uninfected (uninfected); non-obese, living with HIV (HIV+); obese/uninfected; and obese/HIV+. Data are presented as n and then percent of column in parentheses unless otherwise indicated.
| Non-obese | Obese | Total | |||
|---|---|---|---|---|---|
| Uninfected | HIV+ | Uninfected | HIV+ | ||
|
| |||||
| N (% of row) | 438 (19) | 1232 (54) | 385 (17) | 245 (11) | 2300 |
|
| |||||
| Median age (mean, SD) years | 53 (54, 9) | 52 (52, 8) | 53 (54, 10) | 51 (51, 8) | 53 (53, 9) |
|
| |||||
| Men | 399 (91) | 1202 (98) | 345 (90) | 236 (96) | 2182 (95) |
|
| |||||
| Race-Ethnicity | |||||
| White | 85 (19) | 244 (20) | 88 (23) | 37 (15) | 454 (20) |
| African American | 309 (71) | 836 (68) | 241 (63) | 179 (73) | 1565 (68) |
| Hispanic | 32 (7) | 104 (8) | 34 (9) | 19 (8) | 189 (8) |
| Other | 12 (3) | 48 (4) | 22 (6) | 10 (4) | 92 (4) |
|
| |||||
| LDL ≥160 mg/dL | 28 (6) | 60 (5) | 29 (8) | 13 (5) | 130 (6) |
|
| |||||
| HDL <40 mg/dL | 111 (25) | 511 (41) | 165 (43) | 128 (52) | 915 (40) |
|
| |||||
| Triglycerides ≥200 mg/dL | 47 (11) | 327 (27) | 88 (23) | 78 (32) | 540 (23) |
|
| |||||
| Total cholesterol ≥200 mg/dL | 113 (26) | 319 (26) | 100 (26) | 80 (33) | 612 (27) |
|
| |||||
| Statin | 156 (36) | 356 (29) | 202 (52) | 99 (40) | 813 (35) |
|
| |||||
| FIB-4 Index >3.25 | 21 (5) | 109 (9) | 11 (3) | 16 (7) | 157 (7) |
|
| |||||
| eGFR <60 mL/min/1.73 m2 | 30 (7) | 91 (7) | 47 (12) | 21 (8) | 188 (8) |
|
| |||||
| Hemoglobin <12 g/dL | 32 (7) | 149 (12) | 26 (7) | 22 (9) | 229 (10) |
|
| |||||
| Alcohol use | |||||
| Not current | 149 (34) | 417 (34) | 158 (41) | 97 (40) | 821 (36) |
| Low risk | 65 (15) | 278 (23) | 78 (20) | 61 (25) | 482 (21) |
| At risk/heavy or binge | 52 (12) | 186 (15) | 64 (17) | 40 (16) | 342 (15) |
| Abuse/dependence | 172 (39) | 346 (28) | 85 (22) | 47 (19) | 650 (28) |
|
| |||||
| Smoking | |||||
| Non-smoker | 89 (20) | 278 (23) | 104 (27) | 82 (33) | 553 (24) |
| Current smoker | 239 (55) | 645 (52) | 148 (38) | 83 (34) | 1115 (48) |
| Past smoker | 109 (25) | 308 (25) | 132 (34) | 80 (33) | 629 (27) |
|
| |||||
| Cocaine | 194 (44) | 453 (37) | 115 (30) | 81 (33) | 843 (37) |
|
| |||||
| Hepatitis C | 154 (35) | 590 (48) | 101 (26) | 98 (40) | 943 (41) |
|
| |||||
| HTN | 341 (78) | 864 (70) | 343 (89) | 202 (82) | 1750 (76) |
|
| |||||
| CVD | 99 (23) | 218 (18) | 129 (34) | 49 (20) | 495 (22) |
|
| |||||
| Diabetes | 95 (22) | 207 (17) | 152 (39) | 93 (38) | 547 (24) |
|
| |||||
| Non AIDS-Defining Cancer | 28 (6) | 58 (5) | 28 (7) | 12 (5) | 12 (5) |
|
| |||||
| AIDS-Defining Cancer | 2 (0.5) | 19 (2) | 0 (0) | 5 (2) | 26 (1) |
|
| |||||
| HIV-1 RNA (HIV+ only) | |||||
| VL≥500 copies/mL | 0 | 413 (34) | 0 | 83 (34) | 496 (22) |
|
| |||||
| CD4+ Cell Count (HIV+ only) | |||||
| CD4<500 cells/mm3 | 0 | 816 (66) | 0 | 139 (57) | 955 (42) |
Abbreviations: SD: standard deviation; LDL: low density lipoprotein; HDL: high density lipoprotein; statin: HMG-Co-A reductase inhibitor; FIB-4: Fibrosis-4 Index; eGFR: estimated glomerular filtration rate; HTN: blood pressure>=140/90 or receiving antihypertensive medications; CVD: cardiovascular disease.
All variables had complete data except the following: LDL-cholesterol was available for 2232 participants; HDL for 2240; triglycerides for 2266; total cholesterol for 2279; FIB-4 for 2267; albumin for 2290; eGFR for 2297; alcohol use for 2212; smoking for 2297; HIV-1 RNA for 1476; and CD4 count for 1476 participants.