Table 3.
Association between obesity/HIV (sub-classified by HIV-1 RNA status) comorbidity and elevated biomarkers of inflammation, monocyte activation and altered coagulation. Differences significant at p<0.05 are in bold.
| Logistic regression model | Obesity/HIV status | HIV-1 RNA (copies/mL) | Elevated biomarker (i.e highest quartile) Odds Ratio (95% Confidence Interval) |
|||||
|---|---|---|---|---|---|---|---|---|
| IL-6 | sCD14 | D-dimer | ||||||
| OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | |||
| Unadjusted | Non-obese, uninfected | -- | 1 (ref) | <0.01 | 1 (ref) | <0.01 | 1 (ref) | <0.01 |
| Obese, uninfected | -- | 1.54 (1.11-2.13) | 0.92 (0.66-1.27) | 1.48 (1.09-2.03) | ||||
| Non-obese, HIV+ | <500 | 1.06 (0.79-1.42) | 1.07 (0.81-1.40) | 0.74 (0.56-0.99) | ||||
| ≥500 | 1.92 (1.40-2.63) | 1.33 (0.98-1.81) | 1.80 (1.33-2.43) | |||||
| Obese, HIV+ | <500 | 1.67 (1.10-2.53) | 0.63 (0.40-1.01) | 0.75 (0.47-1.19) | ||||
| ≥500 | 1.46 (0.85-2.51) | 0.48 (0.24-0.94) | 1.56 (0.93-2.61) | |||||
| Age, race-ethnicity adjusted | Non-obese, uninfected | -- | 1 (ref) | <0.01 | 1 (ref) | <0.01 | 1 (ref) | <0.01 |
| Obese, uninfected | -- | 1.55 (1.11-2.15) | 0.91 (0.65-1.26) | 1.54 (1.12-2.12) | ||||
| Non-obese, HIV+ | <500 | 1.09 (0.81-1.46) | 1.07 (0.82-1.41) | 0.77 (0.58-1.03) | ||||
| ≥500 | 2.16 (1.57-2.98) | 1.45 (1.07-1.98) | 2.06 (1.51-2.81) | |||||
| Obese, HIV+ | <500 | 1.78 (1.17-2.70) | 0.65 (0.41-1.05) | 0.81 (0.51-1.29) | ||||
| ≥500 | 1.65 (0.96-2.86) | 0.53 (0.27-1.04) | 1.75 (1.04-2.96) | |||||
| Fully adjusted | Non-obese, uninfected | -- | 1 (ref) | <0.01 | 1 (ref) | <0.01 | 1 (ref) | <0.01 |
| Obese, uninfected | -- | 1.60 (1.13-2.28) | 0.77 (0.54-1.09) | 1.36 (0.97-1.90) | ||||
| Non-obese, HIV+ | <500 | 1.05 (0.76-1.44) | 0.90 (0.67-1.21) | 0.73 (0.53-1.00) | ||||
| ≥500 | 1.88 (1.33-2.66) | 1.17 (0.84-1.64) | 1.79 (1.28-2.49) | |||||
| Obese, HIV+ | <500 | 1.89 (1.21-2.96) | 0.48 (0.29-0.80) | 0.72 (0.44-1.17) | ||||
| ≥500 | 1.56 (0.86-2.82) | 0.38 (0.19-0.78) | 1.32 (0.76-2.31) | |||||
Fully adjusted models adjusted for age, race/ethnicity, LDL, HDL, statin use, FIB4, eGFR, alcohol use, smoking, cocaine use, HCV, HTN, CVD, diabetes
Sample size within obesity/HIV/HIV-1 RNA (above or below 500 copies/mL) strata: Non-obese HIV uninfected (438), obese HIV uninfected (385), non-obese HIV+ <500 (819), non-obese HIV+ ≥500 (413), obese HIV+ <500 (161), obese HIV+ ≥500 (83)