Table 3. Fatty acids, carnitine and lysophosphatidyl choline metabolomics in hepatic samples of rat and human.

Fatty acid metabolite values represent natural log transformed AUC values relative to species specific control samples ± the standard deviation.

Fatty acids	Rat			Human			Interspecies Adj. p value
	HFD	MCD	Adj. p value	Steatosis	NASH	Adj. p value
Arachidonic Acid	−0.12±0.57	1.02±0.82	0.056	−1.00±0.51	−0.92±0.60	0.000*	0.000#
Arachidonoyl-lyso-PE (20:4)	0.1±0.31	0.19±0.38	0.589	−0.36±0.13	0.59±0.39	0.000*	0.011#
Butyryl Carnitine (C4)	0.13±0.84	−2.00±2.24	0.116	1.76±0.92	1.75±0.69	0.000*	0.000#
Choline	0.79±0.58	0.20±0.70	0.878	−0.11±0.23	0.57±0.27	0.000*	0.000#
Lauryl Carnitine (C12)	1.62±0.78	−0.17±1.10	1.000	2.25±1.51	2.50±0.81	0.000*	0.000#
Linoleic Acid	0.29±1.43	2.20±1.88	0.110	−1.43±2.25	−2.12±1.45	0.001*	0.000#
Stearoyl Carnitine (C18:0)	1.3±0.48	1.37±0.81	0.016*	0.36±0.35	0.54±0.65	0.020*	0.004#
Stearoyl-lyso-PE (18:0)	0.95±0.52	1.39±0.65	0.001*	−0.54±0.25	−0.86±0.45	0.000*	0.000#
Tetradecanoyl Carnitine (C14)	2.17±0.55	−0.32±1.56	1.000	2.30±0.80	1.48±0.77	0.000*	0.000#

^*represents significant difference across samples for that species,

^#represents for significant difference in human NASH to rat MCD samples. Test statistics calculated conducting the one way ANOVA with Tukey honest significant difference (HSD), with significance define as adjusted p value ≤ 0.05.

Abbreviation: HFD: high fat diet; MCD: methionine and choline deficient; NASH: nonalcoholic steatohepatitis