Table 4. Other metabolomics in hepatic samples of rat and human.

Metabolite values represent natural log transformed AUC values relative to species-specific control samples ± the standard deviation.

Metabolite	Rat			Human			Interspecies Adj. p value
	HFD	MCD	Adj. p value	Steatosis	NASH	Adj. p value
4-hydroxyproline	0.62±1.55	1.03±0.56	0.209	−0.52±1.29	2.99±0.70	0.000*	0.000#
Betaine	−0.02±0.18	−1.03±0.62	0.024*	−0.29±0.29	1.09±0.55	0.000*	0.000#
Creatine	0.30±0.46	0.90±0.32	0.001*	−0.08±0.08	−0.56±0.32	0.000*	0.000#
Creatinine	1.42±0.76	0.83±0.86	0.115	−0.35±0.39	1.03±0.70	0.000*	0.502
Glucose	−0.51±0.53	−1.32±0.71	0.002*	0.41±0.27	0.41±0.54	0.196	0.000#
Taurine	1.03±0.74	0.57±0.55	0.385	0.05±0.05	1.14±0.27	0.000*	0.000#

^*represents significant difference across samples for that species

^#represents for significant difference in human NASH to rat MCD samples. Test statistics calculated conducting the one way ANOVA with Tukey honest significant difference (HSD), with significance define as adjusted p value ≤ 0.05.

Abbreviation: HFD: high fat diet; MCD: methionine and choline deficient; NASH: nonalcoholic steatohepatitis