Table 2.
Characteristics and performance measures available for each method
| Feature | EWAS2 | DSA1 | DSA2 | Sun3step | LASSO | GLINTERNET | BRT |
|---|---|---|---|---|---|---|---|
| Model structure | |||||||
| Provides regression coefficients | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| Able to include interaction terms | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| Able to include confounder covariates | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| Able to capture non-linear associations | ✓ | ✓ | ✓ | ||||
| Measures of performance | |||||||
| RMS | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
| RNV | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| Sens | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
| AltSens | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Sensvar | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Sens2 | ✓ | ✓ | ✓ | ✓ | |||
| AltSens2 | ✓ | ✓ | ✓ | ✓ | |||
| FDP | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
| AltFDP | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| FDPvar | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| FDP2 | ✓ | ✓ | ✓ | ✓ | |||
| AltFDP2 | ✓ | ✓ | ✓ | ✓ | |||