Table 1.
Relationship between STAT3 promoter methylation, patient clinical characteristics and PA invasiveness
| STAT3 gene methylation | ||||
|---|---|---|---|---|
| Number of patients | M (%) | U (%) | p-value | |
| Cases | 102 | 11(10.78) | 91(89.22) | |
| Age (years) | ||||
| ≤ 60 | 40 | 4(10.00) | 36(90.00) | 0.837 |
| > 60 | 62 | 7(11.29) | 55(88.71) | |
| Gender | ||||
| Female | 58 | 6(10.34) | 52(89.66) | 0.870 |
| Male | 44 | 5(11.36) | 39(88.64) | |
| PA function | ||||
| Secreting | 54 | 6(11.11) | 48(88.89) | 0.910 |
| Non-secreting | 48 | 5(10.42) | 43(89.58) | |
| Relapse | ||||
| Appear | 8 | 1(12.50) | 7(87.50) | 0.871 |
| None | 94 | 10(10.64) | 84(89.36) | |
| Prolactinoma | ||||
| Appear | 36 | 4(11.11) | 32(88.89) | 1.000 |
| None | 18 | 2(11.11) | 16(88.89) | |
| Acromegaly | ||||
| Appear | 9 | 1(11.11) | 8(88.89) | 1.000 |
| None | 45 | 5(11.11) | 40(88.89) | |
| Cushing syndrome | ||||
| Appear | 1 | 0(0.00) | 1(100.00) | 0.721 |
| None | 53 | 6(11.32) | 47(88.68) | |
| Hormones | ||||
| PRL | 36 | 4(11.11) | 32(88.89) | |
| IGF-1 | 2 | 0(0.00) | 2(100.00) | |
| GH | 4 | 2 (50.00) | 2(50.00) | |
| ACTH | 1 | 0(0.00) | 1(100.00) | |
| Multiple | 11 | 0(0.00) | 11(100.00) | |
| Invasiveness | ||||
| Invasive | 58 | 7(12.07) | 51(87.93) | 0.428 |
| Non-invasive | 30 | 2(6.67) | 28(93.33) | |
M methylated, U non-methylated, PRL prolactin, IGF-1 insulin-like grow factor 1, GH growth hormone, ACTH – adrenocorticotropic hormone, multiple – PAs secreting more than one hormone