Fig 1. Natural history of CLP in humanized mice.

We observed a significant decrease in animal mortality (A). Most deaths occurred either shortly after surgery or two weeks after the initial insult. Animals who died prematurely exhibited a significant drop in temperature at 6 (p = 0.0043) and 18 h (p = 0012) after CLP, while survivors were able to regain their core temperatures, at least partially (C). Also, the drop in weight was more pronounced in animals dying prematurely (p = 0.025) (C). A strong correlation was observed between drop in temperature at six h and weight loss post-CLP (r² = 0.37;p = 0.023) (D).