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. 2017 Jul 17;12(7):e0180377. doi: 10.1371/journal.pone.0180377

Fig 2. Cytokine production following CLP exhibits a time-dependent pattern.

Fig 2

In the posthoc analysis, MO stimulated with LPS responded with increased production of IL-10 (p = 0.041) and IL-6 (p = 0.003) only at 24 h after CLP. TNFα secretion was increased at t+24 h (p = 0.00001) followed by suppression of TNF production at t+7 d (p = 0.026). After 28 d (t+28 d), production of these cytokines returned to pre-CLP status. Production of GM-CSF was not significantly increased at any time point. Expression of the TLR4 receptor was depressed at t+24 h regarding the percentage of positive cells (p = 0.003) and receptor density (p = 0.0008).