Table 3. Correlation of human serum anti-Neu5Gc IgM and IgG antibodies with vaccination history.
Vaccinations received | ||||||
---|---|---|---|---|---|---|
Vaccine | Anti-NeuGc IgM (N) | Anti-NeuGc IgM (Y) | P Value | Anti-NeuGc IgG (N) | Anti-NeuGc IgG (Y) | P Value |
Bacillus Calmette Guerin | 0.03 ± 0.02 | 0.03 ± 0.02 | 0.25 | 0.09 ± 0.11 | 0.17 ± 0.18 | P<0.05 |
*Diphtheria, Pertussis, Tetanus | 0.04 ± 0.01 | 0.03 ± 0.02 | 0.42 | 0.12 ± 0.06 | 0.15 ± 0.17 | 0.49 |
Haemophilus influenzae type B | 0.03 ± 0.02 | 0.03 ± 0.02 | 0.88 | 0.15 ± 0.17 | 0.13 ± 0.15 | 0.41 |
Hepatitis B | 0.03 ± 0.02 | 0.03 ± 0.02 | 0.84 | 0.08 ± 0.13 | 0.16 ± 0.17 | P<0.05 |
Infuenza | 0.03 ± 0.01 | 0.03 ± 0.02 | 0.87 | 0.15 ± 0.18 | 0.15± 0.16 | 0.94 |
Measles | 0.03 ± 0.01 | 0.03 ± 0.02 | 0.47 | 0.17 ± 0.14 | 0.15 ± 0.17 | 0.3 |
Measles, Mumps, Rubella | 0.03 ± 0.01 | 0.03 ± 0.02 | 0.5 | 0.16 ± 0.12 | 0.15 ± 0.17 | 0.34 |
Oral Poliomyelitis | 0.03 ± 0.01 | 0.03 ± 0.02 | 0.74 | 0.15 ± 0.14 | 0.15± 0.17 | 0.88 |
Typhoid | 0.03 ± 0.02 | 0.03 ± 0.02 | 0.4 | 0.18 ± 0.18 | 0.04 ± 0.05 | P<0.01 |
Varicella Zoster | 0.03 ± 0.02 | 0.03 ± 0.02 | 0.64 | 0.16 ± 0.17 | 0.13 ± 0.15 | 0.72 |
Yellow Fever | 0.03 ± 0.02 | 0.03 ± 0.01 | 0.37 | 0.15 ± 0.17 | 0.12 ± 0.17 | 0.13 |
N = No; Y = Yes
Anti-Neu5Gc IgM/IgG ELISA data are shown in terms of mean OD+/-SD (p value), which was calculated using mean OD minus negative control OD.
Bacillus Calmette Guerin and Heptatitis B vaccines: anti-Neu5Gc IgG (N) vs anti-Neu5Gc IgG (Y) P<0.05.
Typhoid vaccine: anti-Neu5Gc IgG (N) vs anti-Neu5Gc IgG (Y) P<0.01.
*The number who had received the diphtheria/pertussis/tetanus vaccine (n = 3) was too small for statistical analysis.