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. 2017 Jul 17;12(7):e0180768. doi: 10.1371/journal.pone.0180768

Table 3. Correlation of human serum anti-Neu5Gc IgM and IgG antibodies with vaccination history.

Vaccinations received
Vaccine Anti-NeuGc IgM (N) Anti-NeuGc IgM (Y) P Value Anti-NeuGc IgG (N) Anti-NeuGc IgG (Y) P Value
Bacillus Calmette Guerin 0.03 ± 0.02 0.03 ± 0.02 0.25 0.09 ± 0.11 0.17 ± 0.18 P<0.05
*Diphtheria, Pertussis, Tetanus 0.04 ± 0.01 0.03 ± 0.02 0.42 0.12 ± 0.06 0.15 ± 0.17 0.49
Haemophilus influenzae type B 0.03 ± 0.02 0.03 ± 0.02 0.88 0.15 ± 0.17 0.13 ± 0.15 0.41
Hepatitis B 0.03 ± 0.02 0.03 ± 0.02 0.84 0.08 ± 0.13 0.16 ± 0.17 P<0.05
Infuenza 0.03 ± 0.01 0.03 ± 0.02 0.87 0.15 ± 0.18 0.15± 0.16 0.94
Measles 0.03 ± 0.01 0.03 ± 0.02 0.47 0.17 ± 0.14 0.15 ± 0.17 0.3
Measles, Mumps, Rubella 0.03 ± 0.01 0.03 ± 0.02 0.5 0.16 ± 0.12 0.15 ± 0.17 0.34
Oral Poliomyelitis 0.03 ± 0.01 0.03 ± 0.02 0.74 0.15 ± 0.14 0.15± 0.17 0.88
Typhoid 0.03 ± 0.02 0.03 ± 0.02 0.4 0.18 ± 0.18 0.04 ± 0.05 P<0.01
Varicella Zoster 0.03 ± 0.02 0.03 ± 0.02 0.64 0.16 ± 0.17 0.13 ± 0.15 0.72
Yellow Fever 0.03 ± 0.02 0.03 ± 0.01 0.37 0.15 ± 0.17 0.12 ± 0.17 0.13

N = No; Y = Yes

Anti-Neu5Gc IgM/IgG ELISA data are shown in terms of mean OD+/-SD (p value), which was calculated using mean OD minus negative control OD.

Bacillus Calmette Guerin and Heptatitis B vaccines: anti-Neu5Gc IgG (N) vs anti-Neu5Gc IgG (Y) P<0.05.

Typhoid vaccine: anti-Neu5Gc IgG (N) vs anti-Neu5Gc IgG (Y) P<0.01.

*The number who had received the diphtheria/pertussis/tetanus vaccine (n = 3) was too small for statistical analysis.

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