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. 2017 Aug 1;25(15):3922–3946. doi: 10.1016/j.bmc.2017.05.030

Table 1.

Examining Aromatic Moieties at C5.

graphic file with name fx3.jpg

Cpd Ar MIC (μM) IC50 (μM) SI Cpd Ar MIC (μM) IC50 (μM) SI
1 graphic file with name fx4.gif 3.1 ± 1.3 >100 >32 13 graphic file with name fx11.gif 4.4 ± 2.0 89 >21
7 graphic file with name fx5.gif >20 >100 – 14 graphic file with name fx12.gif 3.0 ± 0.21 >100 >30
8 graphic file with name fx6.gif >20 87 – 15 graphic file with name fx13.gif >20 >100 –
9 graphic file with name fx7.gif >20 37 – 16 graphic file with name fx14.gif 0.83 ± 0.26 >100 >130
10 graphic file with name fx8.gif >20 >100 – 17 graphic file with name fx15.gif >20 >100 –
11 graphic file with name fx9.gif >20 65 – 18 graphic file with name fx16.gif >20 69 –
12 graphic file with name fx10.gif >20 >100 – 19 graphic file with name fx17.gif >20 57 –

MIC90 is the minimum concentration required to inhibit growth of M. tuberculosis by 90%. MICs are the average ± standard deviation of two independent experiments. IC50 is the concentration required to reduce the viability of HepG2 cells by 50%. Selectivity index (SI) = IC50/MIC90.