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. 2017 Aug 1;25(15):3922–3946. doi: 10.1016/j.bmc.2017.05.030

Table 5.

C7 Modifications with 2-Pyridyl at C5.

graphic file with name fx52.jpg

Cpd R MIC (μM) IC50 (μM) SI Cpd R MIC (μM) IC50 (μM) SI
51 graphic file with name fx53.gif 2.4 ± 1.3 >100 >46 56 graphic file with name fx58.gif 0.2 ± 0.02 44 220
52 graphic file with name fx54.gif >20 >100 – 57 graphic file with name fx59.gif 4.8 ± 1.3 81 17
53 graphic file with name fx55.gif >20 >100 – 58 graphic file with name fx60.gif 0.98 ± 0.4 >100 >119
54 graphic file with name fx56.gif >20 >100 – 59 graphic file with name fx61.gif 1.6 ± 1.1 >100 >72
55 graphic file with name fx57.gif 0.52 ± 0.1 >100 >196 60 graphic file with name fx62.gif 0.76 ± 0.25 >100 >135

MIC90 is the minimum concentration required to inhibit growth of M. tuberculosis by 90%. MICs are the average ± standard deviation of two independent experiments. IC50 is the concentration required to reduce the viability of HepG2 cells by 50%. Selectivity index (SI) = IC50/MIC90.