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. Author manuscript; available in PMC: 2018 Mar 20.
Published in final edited form as: Chem Res Toxicol. 2017 Mar 1;30(3):785–793. doi: 10.1021/acs.chemrestox.6b00315

Table 1. Kinetic parameters of recombinant ALDH2 following in vitro acetic anhydride treatment.

The decrease in kcat along with an increase in Km concurrent with increasing acetylation suggests mixed inhibition. Values listed are the average ± standard deviation.

[Acetic Anhydride] kcat (min−1) Km (μM)
IC0 15.8 ± 1.2 213 ± 54
IC25 14.1 ± 1.2 285 ± 75
IC50 12.2 ± 1.0 715 ± 129
IC75 11.9 ± 1.3 1530 ± 267
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