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. Author manuscript; available in PMC: 2017 Jul 17.
Published in final edited form as: Nat Rev Clin Oncol. 2016 Jun 14;13(9):581–588. doi: 10.1038/nrclinonc.2016.90

Table 4.

Variation in risk estimates on recommendations

Screening parameters
in relation to age		 Constant
OR 3.0
(1100delC)3 		Constant
OR 2.08
(1100delC)36 		Constant
OR 4.8
(1100delC,
familial)64 		OR declining
with
attained age
(1100delC)40 		Constant
OR 1.58
(I157T)47
Cumulative risk to 80 years 31.8% 23.3% 45.8% 24% 18.3%
Age to initiate mammography (based on 1%-5-year-risk) 40 years 40 years 35 years 40 years 45 years
MRI (based on ≥20% CLTR threshold) Yes Yes Yes Yes No
MRI (based on ≥30% CLTR threshold) Yes No Yes No No
Age when MRI threshold exceeded (based on 2.2% 5-year risk) 45 years 50 years 40 years 45 years NA

CTLR, cumulative lifetime risk; NA, not applicable.