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Compound 8g showed considerably affinity in inhibiting the β-secretase and Aβ aggregation.
| Compound | Aβ aggregation (IC50, μM)a | β-secretase (IC50, μM)** |
|---|---|---|
| 8g | 18.21±2.3 | 23.14±1.8 |
| Curcumin | 11.3±0.3 | 6.1±0.8 |
Data are expressed as means ± standard deviation (SD) of at least three independent experiments.
