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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: JAMA Neurol. 2016 Dec 1;73(12):1485–1490. doi: 10.1001/jamaneurol.2016.3097

Figure 2. Protein Interaction Network for Human Ataxia Genes.

Figure 2

The STRING prediction server (version 9.1) was used to generate the protein network using all the known genes involved in human ataxia syndromes as seeds. The maximum number of predicted neighbors was set to 1000; experiment was selected as search criteria (to include only the experimentally validated physical interactions), and the maximum stringency was chosen (highest confidence score = 0.900). The following 6 subnetworks can be appreciated, each highlighting a specific cellular process: protein translation (red), ubiquitination (blue), transcription regulation (yellow and green), DNA repair (brown), and energy production (orange). TBP indicates TATA-binding protein. A complete list of protein names and symbols is given in eTable 3 in the Supplement. SCA41 and SCA43 were not included because they were published after the manuscript was accepted.