Table 1.

The drugs of ABC7, their targets during treatment of breast cancer, and suggested doses

Drug	Target in breast cancer treatment	Starting dose	Target dose
Capecitabine	DNA synthesis	600 mg/m2 twice daily. 7 days on, 7 days off	1250 mg/m2 twice daily. 7 days on, 7 days off or 14 days on, 7 off
Quetiapine	RANK/RANKL	50 mg once at bedtime	300–600 mg once at bedtime
Pirfenidone	TGF-beta	200 mg three times daily	600 mg three times daily
Rifabutin	BCL-6; beta-catenin	150 mg/day	300 mg/day
Metformin	AMPK*; mTOR; mitochondria oxphos	500 mg once daily	1000 mg twice daily
Propranolol	Beta-adrenergic receptors	10 mg twice daily	Uptitrate as tolerated
Agomelatine	Melatonergic receptors*	25 mg once at bedtime	50 mg once at bedtime
Ribavirin**	eIF4E; MNK; IMPDH	600 mg/day	1200 mg/day

Notes: The drugs are listed in a suggested order of addition. Pace of drug addition is individualized per patient and physician estimations of risk/benefit.

^*Note that all entries denote inhibition of named target except for metformin that activates AMPK and agomelatine that stimulates melatonin receptors. All drugs, except capecitabine, are given continuously without interruption. Capecitabine is given on 7 days on, 7 days off, or 14 days on, 7 days off cycles.

^**Ribavirin is likely to give unpleasant side effects and depressed mood but is potentially a beneficial enough drug to try.