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. Author manuscript; available in PMC: 2017 Jul 17.
Published in final edited form as: Nature. 2016 Nov 30;540(7631):134–138. doi: 10.1038/nature20169

Extended Data Figure 3. Substrate affinity to a targeting pathway depends on the position of its transmembrane domain.

Extended Data Figure 3

Quantification of the mislocalization phenotype in Fig. 2F and Fig. 2G confirms that re-positioning of a substrate’s TMD can alter its dependence on the different targeting pathways.