TABLE 1 .
Global transcriptional responses of ZIKV-infected hBMECs
| Category and protein |
Fold induction versus controls at: |
Confirmed by qRT-PCR |
||||
|---|---|---|---|---|---|---|
| 12 hpi | 1 dpi | 2 dpi | 3 dpi | 9 dpi | ||
| Interferons | ||||||
| IFN-β | 142 | 7 | 4 | X | ||
| IFN-λ1 | 238 | 212 | 4 | X | ||
| IFN-λ2 | 11 | 10 | ||||
| IFN-λ3 | 23 | 23 | 2 | |||
| ISGs | ||||||
| IFIT1 | 62 | 734 | 1,086 | 650 | 2,071 | X |
| IFIT2 | 17 | 1126 | 869 | 68 | 58 | X |
| IFIT3 | 6 | 226 | 434 | 130 | 282 | |
| IFITM1 | 3 | 5 | 5 | 8 | ||
| MX1 | 36 | 515 | 1,081 | 575 | 209 | X |
| OAS2 | 6 | 271 | 961 | 475 | 737 | X |
| RSAD2a | 57 | 193 | 106 | 616 | ||
| ISG15 and related | ||||||
| ISG15 | 28 | 64 | 43 | 90 | X | |
| HERC5 | 5 | 451 | 292 | 52 | 46 | X |
| HERC6 | 36 | 43 | 20 | 26 | ||
| USP18 | 3 | 4 | 7 | 13 | X | |
| USP41 | 3 | 6 | 7 | 13 | ||
| IRFs | ||||||
| IRF1 | 114 | 24 | ||||
| IRF7 | 5 | 9 | 6 | 10 | ||
| IRF9 | 6 | 7 | 3 | 3 | ||
| Transcription factors | ||||||
| ATF3 | 4 | 301 | 101 | 7 | 7 | |
| EGR1 | 7 | 168 | 155 | 20 | ||
| TRAF1 | 86 | 39 | 3 | |||
| JUNB | 4 | 14 | 15 | |||
| Apoptosis regulatory factors | ||||||
| BIRC3 IAP2 | 35 | 43 | 5 | 6 | X | |
| XAF1 | 5 | 62 | 201 | 86 | 50 | X |
| Permeability | ||||||
| Rnd1 | 3 | 169 | 80 | 5 | X | |
| ARHGAP26 RhoAct | 12 | 8 | 2 | |||
| Chemokines and related | ||||||
| CCL5/RANTES | 9 | 2,327 | 1,914 | 352 | 40 | X |
| CXCL10 | 247 | 179 | 35 | 60 | X | |
| CXCL11 | 305 | 244 | 57 | 7 | ||
| CCL20 | 385 | 126 | 8 | |||
| IL-1 | 20 | 11 | 5 | 3 | ||
| IL-6 | 10 | 11 | 3 | 2 | ||
a
MX2 and OAS1 were similarly induced.