Figure 3. In vivo efficacy of EMABling^® 3C23K (low-fucose form) in mice xenografted with COV434- MISRII human ovarian cancer cells.

(A) Comparison with murine 12G4 or NaCl, as vehicle (7–8 mice/group). (B) Comparison with 3C23K-CHO (normal fucose form), 3C23K mutated in the Fc domain (no binding to Fc receptors) and the irrelevant R565 antibody (9 mice/group) and (C) Association with 60 mg/kg carboplatin (CarboPt). Results are presented as (1) tumor growth curves (mean and 95% CI upper bound) and (2) Kaplan–Meier survival curves (percentage of mice with a tumor volume lower than 2,000 mm³ as a function of time after graft).