Table 1. Characteristics of the studies included in the meta-analysis.
Author | Year | Country | Ethnicity | Source | Cancer | Case | Control | MAF | HWE | Score | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BB | Bb | bb | All | BB | Bb | bb | All | |||||||||
rs1047768 T>C | ||||||||||||||||
Shen M | 2005 | China | Asian | PB | Lung | 55 | 49 | 14 | 118 | 63 | 36 | 13 | 112 | 0.28 | 0.037 | 10 |
Zienolddiny S | 2006 | Norway | Caucasian | PB | Lung | 60 | 119 | 137 | 316 | 109 | 126 | 138 | 373 | 0.54 | <0.001 | 11 |
Moreno V | 2006 | Spain | Caucasian | HB | Colorectal | 114 | 184 | 53 | 351 | 105 | 164 | 51 | 320 | 0.42 | 0.325 | 11 |
Garcia-Closas M | 2006 | Spain | Caucasian | HB | Bladder | 188 | 530 | 385 | 1103 | 222 | 506 | 366 | 1094 | 0.57 | 0.052 | 12 |
Xie WM | 2007 | China | Asian | PB | HCC | 194 | 195 | 38 | 427 | 235 | 196 | 48 | 479 | 0.30 | 0.451 | 11 |
Abbasi R | 2009 | Germany | Caucasian | PB | Laryngeal | 43 | 127 | 78 | 248 | 115 | 320 | 212 | 647 | 0.57 | 0.762 | 13 |
Hussain SK | 2009 | China | Asian | PB | Gastric | 97 | 61 | 12 | 170 | 189 | 168 | 29 | 386 | 0.29 | 0.173 | 13 |
Ma H | 2012 | USA | Caucasian | HB | SCCHN | 184 | 506 | 369 | 1059 | 179 | 507 | 379 | 1065 | 0.59 | 0.669 | 11 |
Sakoda LC | 2012 | USA | Caucasian | PB | Lung | 108 | 378 | 256 | 742 | 245 | 722 | 507 | 1474 | 0.59 | 0.656 | 15 |
He J | 2013 | China | Asian | HB | Gastric | 571 | 469 | 85 | 1125 | 610 | 474 | 112 | 1196 | 0.29 | 0.155 | 13 |
Paszkowska-Szczur K | 2013 | Poland | Caucasian | PB | Melanoma | 128 | 291 | 214 | 633 | 242 | 623 | 465 | 1330 | 0.58 | 0.189 | 13 |
Li X | 2014 | China | Asian | HB | Laryngeal | 49 | 101 | 60 | 210 | 46 | 97 | 67 | 210 | 0.55 | 0.333 | 9 |
Mirecka A | 2014 | Poland | Caucasian | HB | Prostate | 128 | 272 | 221 | 621 | 154 | 368 | 259 | 781 | 0.57 | 0.260 | 9 |
Li XC | 2014 | China | Asian | HB | Gastric | 37 | 95 | 85 | 217 | 29 | 93 | 95 | 217 | 0.65 | 0.414 | 8 |
Na N | 2015 | China | Asian | HB | Breast | 161 | 140 | 24 | 325 | 171 | 134 | 20 | 325 | 0.27 | 0.352 | 10 |
Paszkowska-Szczur K | 2015 | Poland | Caucasian | HB | Colorectal | 104 | 221 | 138 | 463 | 242 | 623 | 465 | 1330 | 0.58 | 0.189 | 9 |
He J | 2016 | China | Asian | HB | Neuroblastoma | 135 | 93 | 20 | 248 | 307 | 198 | 26 | 531 | 0.24 | 0.409 | 10 |
Hua RX | 2016 | China | Asian | HB | Colorectal | 970 | 758 | 173 | 1901 | 1023 | 812 | 142 | 1977 | 0.28 | 0.266 | 10 |
Hua RX | 2016 | China | Asian | HB | Gastric | 607 | 445 | 90 | 1142 | 625 | 461 | 87 | 1173 | 0.27 | 0.875 | 11 |
Li RJ | 2016 | China | Asian | HB | Gastric | 57 | 92 | 67 | 216 | 68 | 87 | 61 | 216 | 0.48 | 0.004 | 7 |
Wang MY | 2016 | China | Asian | HB | Prostate | 491 | 433 | 80 | 1004 | 534 | 440 | 81 | 1055 | 0.29 | 0.461 | 10 |
Bai Y | 2016 | China | Asian | HB | Gastric | 41 | 98 | 55 | 194 | 32 | 106 | 87 | 225 | 0.62 | 0.975 | 6 |
rs2296147 T>C | ||||||||||||||||
Shao MH | 2007 | China | Asian | HB | Lung | 570 | 304 | 52 | 926 | 590 | 358 | 31 | 979 | 0.21 | 0.008 | 10 |
Doherty JA | 2011 | USA | Mixed | PB | Endometrial | 194 | 356 | 165 | 715 | 199 | 364 | 157 | 720 | 0.47 | 0.696 | 11 |
Duan Z | 2012 | China | Asian | HB | Gastric | 257 | 122 | 24 | 403 | 260 | 132 | 11 | 403 | 0.19 | 0.232 | 11 |
He J | 2012 | China | Asian | HB | Gastric | 700 | 371 | 54 | 1125 | 742 | 398 | 56 | 1196 | 0.21 | 0.779 | 13 |
Ma H | 2012 | USA | Caucasian | HB | SCCHN | 280 | 532 | 244 | 1056 | 294 | 543 | 228 | 1065 | 0.47 | 0.440 | 11 |
Sakoda LC | 2012 | USA | Caucasian | PB | Lung | 182 | 385 | 174 | 741 | 407 | 723 | 341 | 1471 | 0.48 | 0.565 | 15 |
Zhu ML | 2012 | China | Asian | HB | ESCC | 757 | 305 | 53 | 1115 | 699 | 368 | 50 | 1117 | 0.21 | 0.860 | 13 |
Yang WG | 2012 | China | Asian | HB | Gastric | 208 | 105 | 24 | 337 | 196 | 110 | 41 | 347 | 0.28 | <0.001 | 9 |
Yang B | 2013 | China | Asian | HB | Prostate | 37 | 49 | 143 | 229 | 25 | 46 | 167 | 238 | 0.80 | <0.001 | 8 |
Na N | 2015 | China | Asian | HB | Breast | 188 | 104 | 33 | 325 | 199 | 98 | 28 | 325 | 0.24 | 0.003 | 9 |
Sun Z | 2015 | China | Asian | HB | NPC | 119 | 177 | 76 | 372 | 111 | 180 | 80 | 371 | 0.46 | 0.660 | 11 |
Chen YZ | 2016 | China | Asian | HB | Gastric | 442 | 217 | 33 | 692 | 475 | 264 | 32 | 771 | 0.21 | 0.535 | 11 |
He J | 2016 | China | Asian | HB | Neuroblastoma | 160 | 79 | 9 | 248 | 343 | 170 | 18 | 531 | 0.19 | 0.583 | 10 |
Hua RX | 2016 | China | Asian | HB | Colorectal | 1169 | 644 | 88 | 1901 | 1213 | 692 | 72 | 1977 | 0.21 | 0.027 | 9 |
Hua RX | 2016 | China | Asian | HB | Gastric | 725 | 364 | 53 | 1142 | 746 | 388 | 39 | 1173 | 0.20 | 0.182 | 11 |
rs2227869 G>C | ||||||||||||||||
Shen M | 2005 | China | Asian | PB | Lung | 103 | 14 | 1 | 118 | 100 | 11 | 0 | 111 | 0.05 | 0.583 | 11 |
Garcia-Closas M | 2006 | Spain | Caucasian | HB | Bladder | 1050 | 91 | 2 | 1143 | 1046 | 90 | 0 | 1136 | 0.04 | 0.164 | 12 |
Huang WY | 2006 | USA | Caucasian | PB | Colorectal | 598 | 52 | 1 | 651 | 601 | 60 | 1 | 662 | 0.05 | 0.694 | 14 |
Hooker S | 2008 | USA | African | HB | Prostate | 234 | 20 | 0 | 254 | 274 | 27 | 0 | 301 | 0.05 | 0.415 | 7 |
Hussain SK | 2009 | China | Asian | PB | Gastric | 174 | 13 | 0 | 187 | 314 | 56 | 3 | 372 | 0.08 | 0.773 | 13 |
Ma H | 2012 | USA | Caucasian | HB | SCCHN | 987 | 70 | 2 | 1059 | 974 | 90 | 2 | 1066 | 0.04 | 0.958 | 11 |
Sakoda LC | 2012 | USA | Caucasian | PB | Lung | 1 | 63 | 680 | 744 | 2 | 110 | 1362 | 1474 | 0.96 | 0.886 | 15 |
Santos LS | 2013 | Portugal | Caucasian | HB | Thyroid | 99 | 6 | 1 | 106 | 184 | 27 | 1 | 212 | 0.02 | 0.993 | 8 |
Paszkowska-Szczur K | 2013 | Poland | Caucasian | PB | Melanoma | 567 | 67 | 2 | 636 | 1168 | 162 | 2 | 1332 | 0.06 | 0.137 | 13 |
Mirecka A | 2014 | Poland | Caucasian | HB | Prostate | 485 | 83 | 3 | 571 | 682 | 99 | 1 | 782 | 0.06 | 0.181 | 9 |
Paszkowska-Szczur K | 2015 | Poland | Caucasian | HB | Colorectal | 372 | 55 | 2 | 429 | 1168 | 162 | 2 | 1332 | 0.06 | 0.137 | 9 |
rs2094258 C>T | ||||||||||||||||
He J | 2012 | China | Asian | HB | Gastric | 457 | 518 | 150 | 1125 | 457 | 560 | 179 | 1196 | 0.62 | 0.728 | 13 |
Ma H | 2012 | USA | Caucasian | HB | SCCHN | 706 | 295 | 37 | 1038 | 721 | 291 | 41 | 1053 | 0.82 | 0.092 | 11 |
Yang WG | 2012 | China | Asian | HB | Gastric | 131 | 149 | 57 | 337 | 145 | 166 | 36 | 347 | 0.66 | 0.252 | 10 |
Zhu ML | 2012 | China | Asian | HB | ESCC | 414 | 524 | 177 | 1115 | 424 | 525 | 168 | 1117 | 0.61 | 0.793 | 13 |
Yang B | 2013 | China | Asian | HB | Prostate | 61 | 75 | 93 | 229 | 58 | 75 | 105 | 238 | 0.40 | <0.001 | 9 |
Na N | 2015 | China | Asian | HB | Breast | 102 | 157 | 66 | 325 | 131 | 147 | 47 | 325 | 0.63 | 0.581 | 10 |
Sun Y | 2015 | China | Asian | HB | Laryngeal | 140 | 106 | 25 | 271 | 152 | 101 | 18 | 271 | 0.75 | 0.826 | 11 |
Sun Z | 2015 | China | Asian | HB | NPC | 209 | 68 | 95 | 372 | 211 | 66 | 94 | 371 | 0.66 | <0.001 | 10 |
Chen YZ | 2016 | China | Asian | HB | Gastric | 287 | 304 | 101 | 692 | 291 | 368 | 112 | 771 | 0.62 | 0.803 | 11 |
He J | 2016 | China | Asian | HB | Neuroblastoma | 116 | 93 | 39 | 248 | 203 | 254 | 74 | 531 | 0.62 | 0.701 | 10 |
Hua RX | 2016 | China | Asian | HB | Colorectal | 797 | 856 | 248 | 1901 | 899 | 881 | 197 | 1977 | 0.68 | 0.378 | 10 |
Feng YB | 2016 | China | Asian | HB | Gastric | 15 | 75 | 87 | 177 | 15 | 96 | 127 | 238 | 0.26 | 0.577 | 6 |
Hua RX | 2016 | China | Asian | HB | Gastric | 499 | 508 | 135 | 1142 | 527 | 524 | 122 | 1173 | 0.67 | 0.623 | 11 |
Lu JJ | 2016 | China | Asian | HB | Gastric | 17 | 67 | 100 | 184 | 13 | 72 | 121 | 206 | 0.24 | 0.605 | 6 |
Ma SH | 2016 | China | Asian | HB | Breast | 27 | 136 | 157 | 320 | 15 | 96 | 127 | 238 | 0.26 | 0.577 | 7 |
Yang LQ | 2016 | China | Asian | HB | Gastric | 71 | 74 | 10 | 155 | 121 | 111 | 14 | 246 | 0.72 | 0.076 | 6 |
Ying MF | 2016 | China | Asian | HB | Pancreatic | 87 | 92 | 16 | 195 | 117 | 115 | 22 | 254 | 0.69 | 0.400 | 7 |
rs751402 C>T | ||||||||||||||||
Shao MH | 2007 | China | Asian | HB | Lung | 105 | 429 | 433 | 967 | 110 | 425 | 448 | 983 | 0.67 | 0.544 | 11 |
Yoon AJ | 2011 | Taiwan | Asian | HB | HCC | 11 | 52 | 33 | 96 | 32 | 137 | 167 | 336 | 0.70 | 0.614 | 6 |
Duan Z | 2012 | China | Asian | HB | Gastric | 47 | 181 | 172 | 400 | 29 | 165 | 206 | 400 | 0.72 | 0.605 | 11 |
He J | 2012 | China | Asian | HB | Gastric | 148 | 491 | 486 | 1125 | 137 | 499 | 560 | 1196 | 0.68 | 0.110 | 13 |
Zavras AI | 2012 | Taiwan | Mixed | HB | OSCC | 31 | 110 | 98 | 239 | 32 | 137 | 167 | 336 | 0.70 | 0.614 | 9 |
Meng X | 2013 | China | Asian | HB | Salivary gland | 11 | 63 | 59 | 133 | 23 | 55 | 64 | 142 | 0.64 | 0.065 | 8 |
Na N | 2015 | China | Asian | HB | Breast | 45 | 152 | 128 | 325 | 41 | 147 | 137 | 325 | 0.65 | 0.872 | 10 |
Sun Z | 2015 | China | Asian | HB | NPC | 237 | 118 | 17 | 372 | 235 | 117 | 19 | 371 | 0.21 | 0.377 | 11 |
Wang H | 2016 | China | Asian | HB | Breast | 1 | 10 | 90 | 101 | 11 | 39 | 51 | 101 | 0.70 | 0.398 | 9 |
Chen YZ | 2016 | China | Asian | HB | Gastric | 93 | 313 | 286 | 692 | 89 | 331 | 351 | 771 | 0.67 | 0.416 | 11 |
He J | 2016 | China | Asian | HB | Neuroblastoma | 38 | 114 | 96 | 248 | 82 | 241 | 208 | 531 | 0.62 | 0.380 | 10 |
Hua RX | 2016 | China | Asian | HB | Colorectal | 248 | 860 | 792 | 1900 | 301 | 952 | 724 | 1977 | 0.61 | 0.680 | 10 |
Guo BW | 2016 | China | Asian | HB | Gastric | 22 | 73 | 47 | 142 | 21 | 136 | 117 | 274 | 0.68 | 0.029 | 5 |
Feng YB | 2016 | China | Asian | HB | Gastric | 24 | 83 | 70 | 177 | 28 | 107 | 101 | 236 | 0.65 | 0.967 | 6 |
Hua RX | 2016 | China | Asian | HB | Gastric | 161 | 555 | 426 | 1142 | 189 | 551 | 433 | 1173 | 0.60 | 0.537 | 11 |
Li RJ | 2016 | China | Asian | HB | Gastric | 22 | 106 | 88 | 216 | 18 | 103 | 95 | 216 | 0.68 | 0.174 | 8 |
Lu JJ | 2016 | China | Asian | HB | Gastric | 24 | 91 | 69 | 184 | 22 | 97 | 87 | 206 | 0.66 | 0.510 | 6 |
Ma SH | 2016 | China | Asian | HB | Breast | 43 | 150 | 127 | 320 | 28 | 101 | 107 | 236 | 0.67 | 0.580 | 7 |
Yang LQ | 2016 | China | Asian | HB | Gastric | 33 | 73 | 49 | 155 | 32 | 111 | 103 | 246 | 0.64 | 0.807 | 6 |
Wang MY | 2016 | China | Asian | HB | Prostate | 104 | 458 | 442 | 1004 | 111 | 467 | 477 | 1055 | 0.67 | 0.834 | 10 |
Zhou RM | 2016 | China | Asian | HB | Gastric | 61 | 196 | 174 | 431 | 46 | 193 | 193 | 432 | 0.67 | 0.827 | 12 |
rs873601 G>A | ||||||||||||||||
Shao MH | 2007 | China | Asian | HB | Lung | 260 | 493 | 220 | 973 | 277 | 494 | 217 | 988 | 0.47 | 0.907 | 11 |
He J | 2012 | China | Asian | HB | Gastric | 274 | 560 | 291 | 1125 | 327 | 605 | 264 | 1196 | 0.47 | 0.616 | 13 |
Ma H | 2012 | USA | Caucasian | HB | SCCHN | 66 | 427 | 565 | 1058 | 83 | 411 | 572 | 1066 | 0.73 | 0.445 | 11 |
Sakoda LC | 2012 | USA | Caucasian | PB | Lung | 51 | 299 | 392 | 742 | 107 | 584 | 783 | 1474 | 0.73 | 0.894 | 15 |
Yang WG | 2012 | China | Asian | HB | Gastric | 96 | 163 | 78 | 337 | 91 | 164 | 91 | 346 | 0.50 | 0.333 | 10 |
Zhu ML | 2012 | China | Asian | HB | ESCC | 314 | 566 | 235 | 1115 | 311 | 565 | 241 | 1117 | 0.47 | 0.601 | 13 |
Na N | 2015 | China | Asian | HB | Breast | 99 | 156 | 70 | 325 | 109 | 150 | 66 | 325 | 0.43 | 0.276 | 10 |
Zhao F | 2015 | China | Asian | HB | Pancreatic | 105 | 111 | 30 | 246 | 118 | 107 | 21 | 246 | 0.30 | 0.637 | 8 |
Chen YZ | 2016 | China | Asian | HB | Gastric | 172 | 333 | 187 | 692 | 205 | 396 | 170 | 771 | 0.48 | 0.415 | 11 |
He J | 2016 | China | Asian | HB | Neuroblastoma | 70 | 112 | 66 | 248 | 137 | 270 | 124 | 531 | 0.49 | 0.686 | 10 |
Wang B | 2016 | China | Asian | HB | HCC | 163 | 271 | 104 | 538 | 271 | 408 | 214 | 893 | 0.47 | 0.014 | 12 |
Hua RX | 2016 | China | Asian | HB | Colorectal | 476 | 954 | 471 | 1901 | 550 | 1025 | 402 | 1977 | 0.46 | 0.057 | 10 |
Hua RX | 2016 | China | Asian | HB | Gastric | 311 | 557 | 274 | 1142 | 323 | 598 | 252 | 1173 | 0.47 | 0.424 | 11 |
Zhou RM | 2016 | China | Asian | HB | Gastric | 115 | 215 | 101 | 431 | 132 | 200 | 100 | 432 | 0.46 | 0.152 | 12 |
Abbreviations: HB, hospital-based; PB, population-based; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism; MAF, minor allele frequency; HWE, Hardy-Weinberg equilibrium; HCC, hepatocellular carcinoma; SCCHN, squamous cell carcinoma of the head and neck; ESCC, esophageal squamous cell carcinoma; OSCC, oral squamous cell carcinoma; NPC, nasopharyngeal carcinoma.