Table 2. Associations between the six SNPs in the XPG gene and cancer risk.
| Variables | No. of studies | No. of cases | No. of controls | Homozygous | Heterozygous | Recessive | Dominant | Allele | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR(95% CI) | P het | OR(95% CI) | P het | OR(95% CI) | P het | OR(95% CI) | P het | OR(95% CI) | P het | ||||
| rs1047768 T>C | CC vs. TT | CT vs. TT | CC vs. CT/TT | CC/CT vs. TT | C vs. T | ||||||||
| All | 22 | 12833 | 15186 | 1.03 (0.95–1.11) | 0.010 | 1.03 (0.97–1.09) | 0.192 | 1.00 (0.93–1.07) | 0.171 | 1.03 (0.98–1.09) | 0.038 | 1.01 (0.98–1.05) | 0.012 |
| Ethnicity | |||||||||||||
| Caucasian | 9 | 5536 | 7084 | 1.03 (0.88–1.21) | 0.012 | 1.04 (0.95–1.14) | 0.061 | 1.00 (0.93–1.07) | 0.344 | 1.04 (0.90–1.20) | 0.011 | 1.01 (0.94–1.10) | 0.011 |
| Asian | 13 | 7297 | 8102 | 1.03 (0.92–1.16) | 0.081 | 1.02 (0.96–1.10) | 0.493 | 1.00 (0.90–1.11) | 0.116 | 1.03 (0.96–1.10) | 0.304 | 1.02 (0.97–1.07) | 0.105 |
| Cancer type | |||||||||||||
| Lung | 3 | 1176 | 1959 | 1.32 (1.06–1.64) | 0.175 | 1.35 (1.10–1.65) | 0.278 | 1.08 (0.92–1.26) | 0.360 | 1.35 (1.12–1.63) | 0.172 | 1.14 (1.02–1.27) | 0.059 |
| Colorectal | 3 | 2715 | 3627 | 0.95 (0.63–1.45) | 0.006 | 0.96 (0.86–1.08) | 0.480 | 0.99 (0.70–1.39) | 0.012 | 0.94 (0.78–1.14) | 0.133 | 0.99 (0.91–1.07) | 0.020 |
| Gastric | 6 | 3064 | 3413 | 0.88 (0.74–1.05) | 0.118 | 0.98 (0.88–1.09) | 0.263 | 0.88 (0.74–1.05) | 0.279 | 0.97 (0.87–1.07) | 0.127 | 0.93 (0.82–1.04) | 0.073 |
| Others | 10 | 5878 | 7517 | 1.04 (0.93–1.15) | 0.507 | 1.05 (0.96–1.14) | 0.670 | 1.01 (0.93–1.10) | 0.725 | 1.05 (0.97–1.14) | 0.628 | 1.03 (0.98–1.08) | 0.659 |
| rs2296147 T>C | CC vs. TT | CT vs. TT | CC vs. CT/TT | CC/CT vs. TT | C vs. T | ||||||||
| All | 15 | 11327 | 12684 | 1.10 (1.00–1.12) | 0.068 | 0.95 (0.90–1.01) | 0.480 | 1.08 (0.99–1.18) | 0.057 | 0.97 (0.92–1.03) | 0.297 | 1.00 (0.96–1.04) | 0.118 |
| Gastric | 5 | 3699 | 3890 | 1.11 (0.76–1.60) | 0.026 | 0.95 (0.86–1.04) | 0.945 | 1.13 (0.78–1.63) | 0.025 | 0.96 (0.88–1.06) | 0.697 | 0.99 (0.91–1.07) | 0.197 |
| rs2227869 G>C | CC vs. GG | GC vs. GG | CC vs. GC/GG | GC/CC vs. GG | C vs. G | ||||||||
| All | 11 | 5898 | 7448 | 1.67 (0.82–3.41) | 0.924 | 0.90 (0.80–1.02) | 0.153 | 0.98 (0.73–1.32) | 0.699 | 0.92 (0.81–1.03) | 0.108 | 0.93 (0.83–1.04) | 0.079 |
| PB | 5 | 2336 | 3951 | 1.08 (0.37–3.10) | 0.793 | 0.80 (0.65–0.99) | 0.239 | 0.89 (0.65–1.21) | 0.766 | 0.81 (0.66–1.00) | 0.170 | 0.84 (0.71–0.99) | 0.115 |
| HB | 6 | 3562 | 4829 | 2.46 (0.91–6.67) | 0.852 | 0.96 (0.82–1.11) | 0.198 | 2.48 (0.91–6.74) | 0.865 | 0.98 (0.84–1.13) | 0.190 | 1.00 (0.87–1.15) | 0.202 |
| rs2094258 C>T | TT vs. CC | CT vs. CC | TT vs. CT/CC | CT/TT vs. CC | T vs. C | ||||||||
| All | 17 | 9826 | 10552 | 1.09 (1.00–1.19) | 0.025 | 1.00 (0.94–1.07) | 0.314 | 1.07 (0.99–1.16) | 0.089 | 1.02 (0.97–1.09) | 0.081 | 1.03 (0.99–1.08) | 0.015 |
| Gastric | 7 | 3812 | 4177 | 0.99 (0.86–1.15) | 0.083 | 0.95 (0.86–1.05) | 0.734 | 1.01 (0.89–1.14) | 0.119 | 0.96 (0.88–1.06) | 0.409 | 0.98 (0.92–1.05) | 0.133 |
| rs751402 C>T | TT vs. CC | CT vs. CC | TT vs. CT/CC | CT/TT vs. CC | T vs. C | ||||||||
| All | 21 | 10369 | 11207 | 1.18 (1.00–1.39) | <0.001 | 1.10 (0.99–1.23) | 0.082 | 1.02 (0.94–1.10) | 0.006 | 1.11 (0.98–1.25) | <0.001 | 1.08 (0.98–1.18) | <0.001 |
| Gastric | 10 | 4664 | 5150 | 1.38 (1.12–1.70) | 0.020 | 1.14 (1.05–1.24) | 0.936 | 1.27 (1.06–1.51) | 0.053 | 1.17 (1.08–1.26) | 0.437 | 1.17(1.07–1.27) | 0.043 |
| rs873601 G>A | AA vs. GG | GA vs. GG | AA vs. GA/GG | GA/AA vs. GG | A vs. G | ||||||||
| All | 14 | 10873 | 12535 | 1.14 (1.06–1.24) | 0.193 | 1.06 (0.99–1.13) | 0.904 | 1.08 (0.99–1.17) | 0.035 | 1.08 (1.02–1.15) | 0.841 | 1.06 (1.02–1.10) | 0.234 |
| Gastric | 5 | 3727 | 3918 | 1.18 (1.04–1.34) | 0.333 | 1.04 (0.93–1.16) | 0.663 | 1.16 (1.04–1.28) | 0.263 | 1.08 (0.98–1.20) | 0.578 | 1.09 (1.02–1.16) | 0.336 |