Table 1.
Demographic and Clinical Characteristics of the Patients.*
| Characteristic | Cord-Blood Group (N = 140) | HLA-Matched Group (N = 344) | HLA-Mismatched Group (N = 98) |
|---|---|---|---|
| Age — yr† | |||
| Median | 29 | 40 | 45 |
| Range | 1–64 | 1–67 | 2–64 |
| Weight — kg† | |||
| Median | 70 | 76 | 77 |
| Range | 9–112 | 13–173 | 12–142 |
| Female sex — no. (%) | 68 (49) | 150 (44) | 45 (46) |
| Race — no. (%)†‡ | |||
| White | 64 (46) | 294 (85) | 76 (78) |
| Other | 76 (54) | 50 (15) | 22 (22) |
| Positive serostatus for cytomegalovirus — no. (%) | 86 (61) | 178 (52) | 47 (48) |
| Diagnosis — no. (%) | |||
| Acute myeloid leukemia | 73 (52) | 175 (51) | 52 (53) |
| Acute lymphoid leukemia | 51 (36) | 106 (31) | 28 (29) |
| Myelodysplastic syndrome | 16 (11) | 63 (18) | 18 (18) |
| Disease risk — no. (%)§ | |||
| Low or intermediate | 93 (66) | 276 (80) | 77 (79) |
| High or very high | 47 (34) | 68 (20) | 21 (21) |
| Conditioning regimen — no. (%)† | |||
| Fludarabine, cyclophosphamide, and total-body irradiation at a dose of 1320 cGy | 97 (69) | 0 | 0 |
| Treosulfan, fludarabine, and total-body irradiation at a dose of 200 cGy | 43 (31) | 64 (19) | 7 (7) |
| Busulfan with either cyclophosphamide or fludarabine | 0 | 127 (37) | 54 (55) |
| Cyclophosphamide and total body irradiation at a dose of 1200 or 1320 cGy | 0 | 153 (44) | 37 (38) |
| GVHD prophylaxis — no. (%)† | |||
| Cyclosporine and mycophenolate mofetil | 140 (100) | — | — |
| Tacrolimus and methotrexate | — | 268 (78) | 98 (100) |
| Other | — | 76 (22) | — |
| Presence of minimal residual disease — no./total no. (%) | 45/137 (33) | 104/331 (31) | 35/90 (39) |
*
The chi-square test was used for categorical variables, and analysis of variance for continuous variables. GVHD denotes graft-versus-host disease.
†
P<0.001 for the difference in the distribution of characteristics among the three groups.
‡
Race was self-reported.
§
Disease risk was categorized as low, intermediate, high, or very high, as previously described.14 P<0.01 for the difference in the distribution of characteristics among the three groups.