Table 2.
Adjusted Cox Regression Models for Analyses of Death and Relapse, According to Minimal Residual Disease Status.*
| Outcome | Hazard Ratio (95% CI) | P Value |
|---|---|---|
| Death | ||
|
| ||
| Patients without minimal residual disease | ||
| Cord-blood group | 1.00 | — |
| HLA-matched group | 0.78 (0.48–1.28) | 0.33 |
| HLA-mismatched group | 1.36 (0.76–2.46) | 0.30 |
|
| ||
| Patients with minimal residual disease | ||
| Cord-blood group | 1.00 | — |
| HLA-matched group | 1.69 (0.94–3.02) | 0.08 |
| HLA-mismatched group | 2.92 (1.52–5.63) | 0.001 |
|
| ||
| Relapse | ||
|
| ||
| Patients without minimal residual disease | ||
| Cord-blood group | 1.00 | — |
| HLA-matched group | 1.30 (0.65–2.58) | 0.46 |
| HLA-mismatched group | 1.28 (0.51–3.25) | 0.60 |
|
| ||
| Patients with minimal residual disease | ||
| Cord-blood group | 1.00 | |
| HLA-matched group | 2.92 (1.34–6.35) | 0.007 |
| HLA-mismatched group | 3.01 (1.22–7.38) | 0.02 |
The analyses were adjusted for age (as a cubic polynomial), severity of disease, year of transplantation (as a continuous linear variable), use or nonuse of high-dose total-body irradiation, and presence or absence of minimal residual disease (in cases in which the interaction with donor group was not deemed to be important). Data on minimal residual disease status were missing for 3 patients in the cord-blood group, for 13 in the HLA-matched group, and for 8 in the HLA-mismatched group.