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Infection and Immunity logoLink to Infection and Immunity
. 1980 Dec;30(3):728–733. doi: 10.1128/iai.30.3.728-733.1980

Humoral and cellular immunity to hepatitis B virus-derived antigens: comparative activity of Freund complete adjuvant alum, and liposomes.

Y Sanchez, I Ionescu-Matiu, G R Dreesman, W Kramp, H R Six, F B Hollinger, J L Melnick
PMCID: PMC551376  PMID: 7014445

Abstract

Complete Freud adjuvant, aluminum gel, and liposomes were compared for their ability to enhance the immunogenicity of an intact 22-nm HBsAg particle vaccine and an HBsAg-derived polypeptide vaccine in guinea pigs. Both humoral and cell-mediated immune responses were evaluated. The greatest immune response was obtained with complete Freund adjuvant, regardless of the antigen preparation. Aluminum gel appeared to be a better adjuvant for 22-nm HBsAg particles, but the liposomes rendered polypeptide preparations more immunogenic. The possibility that various proportions were entrapped in aqueous compartments instead of being inserted into the lipid bilayers of liposomes might account for this difference. The development of both humoral and cellular immunity was dependent upon the use of an adjuvant, because aqueous preparations had poor immunogenicity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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