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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2017 Jan 17;1868(1):16–28. doi: 10.1016/j.bbcan.2017.01.001

Figure 3. Implications of differential miRNA expression on racial cancer health disparities.

Figure 3

Expression of miR-182 and miR-212 has been shown to be influenced by methylation. In AA prostate cancer patients, lower miR-212 expression results in abrogation of suppression of its target hnRNP H1. Conversely, a higher miR-182 expression in AA colorectal cancer patients leads to suppression of its target CHL1 which can, additionally, itself be regulated through differential methylation of its own CpG islands. This model describes the complex interplay of multiple epigenetic events, namely, methylation and regulation through miRNAs, in making an impact on the racially disparate cancer outcomes.