Table 3.
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Reaction conditions: 1a (35.6 mg, 0.1 mmol), Aminating reagent (1.5 equiv.), Pd(OAc)2 (15 mol%), L28 (15 mol%), NBE-CO2Me (42.8 mg, 3 equiv.), AgOAc (50.1 mg, 3.0 equiv.), CH2Cl2 (1.0 mL), 100 °C, Air, 24 h.
Isolated yield.
Pd(OAc)2 (10 mol%), L28 (10 mol%), NBE-CO2Me (21.4 mg, 1.5 equiv.), AgOAc (33.4 mg, 2.0 equiv.) were used.