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. Author manuscript; available in PMC: 2018 Apr 7.
Published in final edited form as: J Am Chem Soc. 2016 Oct 13;138(42):14092–14099. doi: 10.1021/jacs.6b08942

Table 5.

Meta-Alkynylation of Anilinesa,b

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a

Reaction conditions: 1 (0.1 mmol), 9 (52.2 mg, 0.2 mmol), Pd(OAc)2 (2.2 mg, 10 mol%), L18 (8.2 mg, 30 mol%), NBE-CO2Me (38.0 mg, 2.5 equiv.), Ag2CO3 (41.3 mg, 1.5 equiv.), LiF (5.2 mg, 0.2 mmol), CH2Cl2 (1.0 mL), 100 °C, Air, 24 h.

b

Isolated yield.