Table 2.
Baseline characteristics of chronic hepatitis B virus carriers affected and unaffected with cirrhosis and/or hepatocellular carcinoma
| Baseline characteristics | Cirrhosis
|
Non-cirrhotic HCC in 4 years of follow-up (n=21) No. (%) |
||
|---|---|---|---|---|
| Control (n=577) No. (%) |
Cirrhosis only in 9 years of follow-up (n=110) No. (%) |
Cirrhotic HCC in 9 years of follow-up (n=67) No. (%) |
||
| Cigarette smokinga | ||||
| No | 350 (60.9) | 66 (60.0) | 37 (55.2) | 10 (47.6) |
| Yes | 225 (39.1) | 44 (40.0) | 30 (44.8) | 11 (52.4) |
| Alcohol drinkingb | ||||
| No | 491 (85.5) | 97 (88.2) | 56 (83.6) | 13 (65.0) |
| Yes | 83 (14.5) | 13 (11.8) | 11 (16.4) | 7 (35.0) |
| Body mass index (kg/m2)c | ||||
| <27 | 456 (79.0) | 82 (74.6) | 57 (85.1) | 0 (0.0) |
| ≥27 | 121 (21.0) | 28 (25.5) | 10 (14.9) | 21 (100.0) |
| Family history of HCC | ||||
| No | 548 (95.0) | 103 (93.6) | 62 (92.5) | 18 (85.7) |
| Yes | 29 (5.0) | 7 (6.4) | 5 (7.5) | 3 (14.3) |
| Serum ALT level (U/L) | ||||
| <45 | 552 (95.7) | 87 (79.1) | 57 (85.1) | 16 (76.2) |
| ≥45 | 25 (4.3) | 23 (20.9) | 10 (14.9) | 5 (23.8) |
| Anti-HCVd | ||||
| Negative | 532 (92.2) | 99 (90.0) | 61 (92.4) | 19 (95.0) |
| Positive | 45 (7.8) | 11 (10.0) | 5 (7.6) | 1 (5.0) |
| HBeAg seropositivitye | ||||
| No | 489 (86.9) | 63 (58.3) | 35 (55.6) | 14 (73.7) |
| Yes | 74 (13.1) | 45 (41.7) | 28 (44.4) | 5 (26.3) |
| HBsAg level (IU/mL)f | ||||
| <1000 | 323 (62.5) | 20 (21.1) | 15 (40.5) | 5 (62.5) |
| ≥1000 | 194 (37.5) | 75 (79.0) | 22 (59.5) | 3 (37.5) |
| HBV DNA level (copies/mL)g | ||||
| <10000 | 364 (66.8) | 16 (16.7) | 7 (13.2) | 4 (30.8) |
| ≥10000 | 181 (33.2) | 80 (83.3) | 46 (86.8) | 9 (69.2) |
| AFB1-albumin adducts (fmol/mg) | ||||
| Undetectable | 154 (26.7) | 23 (20.9) | 6 (9.0) | 2 (9.5) |
| Low (<21.5) | 196 (34.0) | 33 (30.0) | 17 (25.4) | 5 (23.8) |
| High (≥21.5) | 227 (39.3) | 54 (49.1) | 44 (65.7) | 14 (66.7) |
2 controls were missing for baseline smoking status.
3 controls and 1 non-cirrhotic HCC case were missing for baseline drinking status.
1 cirrhosis only case was missing for baseline BMI data.
1 cirrhotic HCC case, and 1 non-cirrhotic HCC case were missing for baseline anti-HCV serostatus.
14 controls, 2 cirrhosis only cases, 4 cirrhotic HCC cases, and 2 non-cirrhotic HCC cases were missing for baseline serostatus of HBeAg.
60 controls, 15 cirrhosis only cases, 30 cirrhotic HCC cases, and 13 non-cirrhotic HCC cases were missing for baseline serum HBsAg level.
32 controls, 14 cirrhosis cases, 14 cirrhotic HCC cases, and 8 non-cirrhotic HCC cases were missing for baseline serum HBV DNA level.