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. 2017 Jul 11;12:4963–4979. doi: 10.2147/IJN.S138400

Figure 5.

Figure 5

Antago-miR155-AuNP rescues the cardiac function in ovariectomized diabetic mice.

Notes: (A) Representative WGA-stained sections from the left ventricular mid-chamber of the above mice. (B) Representative images of the Masson staining of ctrl and antago-miR155 AuNP-treated heart. (C) Quantitative data of the cardiomyocyte size in the indicated groups (n=4). (D) Quantitative data of the fibrotic area in the indicated groups (mean ± SEM, n=4 mice in each group). (E) Apoptotic cells in the hearts of ovariectomized diabetic mice after control and antago-miR155 treatment were probed by TUNEL staining. (F) Quantitative data of the apoptotic cells in the indicated groups (n=4). LVEF (G) and LVFS (H) values of cardiac systolic function in the aforementioned mice (mean ± SD, n=5 mice in each group). Scale bars =50 μm and apply to all images. **P<0.01, ***P<0.001.

Abbreviations: AuNP, gold nanoparticle; Ctrl, control; Hoechst, Hoechst 33258; LVEF, left ventricular ejection fraction; LVFS, left ventricular fraction shortening; NC, negative control; SD, standard deviation; TUNEL, terminal deoxynucleotidyl transferase mediated dUTP nick end labeling; WGA, wheat germ agglutinin.