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. 2017 Jul 5;174(15):2563–2575. doi: 10.1111/bph.13868

Figure 5.

Figure 5

Effect of guanylate cyclase and adenylate cyclase inhibition on vasodilatation induced by PDE1 inhibition in rat mesenteric arteries. Concentration–response curves for Lu AF41228 in (A) phenylephrine‐contracted arteries incubated with vehicle (n = 6); an inhibitor of guanylate cyclase, ODQ (n = 6); an inhibitor of adenylate cyclase, SQ22536 (n = 6); or the combination of ODQ and SQ22536 (n = 5), and (B) U46619‐contracted arteries incubated with vehicle (n = 6), ODQ (n = 6), SQ22536 (n = 6) or the combination of ODQ and SQ22536 (n = 5). Concentration–response curves for Lu 58027 in (C) phenylephrine‐contracted arteries incubated with vehicle (n = 6); an inhibitor of guanylate cyclase, ODQ (n = 7); an inhibitor of adenylate cyclase, SQ22536 (n = 5); or the combination of ODQ and SQ22536 (n = 6), and (D) U46619‐contracted arteries incubated with vehicle (n = 6), ODQ (n = 7), SQ22536 (n = 5) or the combination of ODQ and SQ22536 (n = 6). Data are means ± SEM. *P < 0.05, significantly different from vehicle control.