Figure 7.

BP and HR changes in response to PDE1 inhibition in telemetered rats. Rats were dosed once with three different doses of Lu AF41228 (A, B, C) or twice daily with a single dose of Lu AF41228 for 7 days (D, E, F). Dotted vertical line represents time of dosing. All experiments are n = 6 except for exposure evaluations. (A) Lu AF41228 did not lead to statistically significant changes in mean arterial BP at any dose tested (maximum 60 mg·kg⁻¹). (B) Lu AF41228 resulted in dose‐dependent increases in HR immediately after dosing. (C) After repeated dosing, Lu AF41228 resulted in a minor decrease in mean arterial BP (P < 0.05 after 0.25 and 0.5 h at day 8 and after 0.5 and 1 h at days 10 and 14). (D) After repeated dosing, Lu AF41228 resulted in an increase in HR immediately after dosing. The effect was similar at days 8, 10 and 14 (P < 0.05 after 0.25 and 0.5 and 1 h at day 8 and after 0.25 and 0.5 h at days 10 and 14).