Table 1.
CB1 receptor agonist potencies/efficacies under various stimulation conditions (summary data)
| 3HA‐hCB1 HEK | ||||||
|---|---|---|---|---|---|---|
| ‐PTX | +PTX | |||||
| pEC50 (M) (± SEM) | EMAX (% of FSK) (± SEM) | n | pEC50 (M) (± SEM) | EMAX (% of FSK) (± SEM) | n | |
| CP55,940 | 9.19 (0.18) | 43.79 (1.28) | 5 | 8.04 (0.03) | 134.86 (5.82) | 5 |
| AEA | 7.47 (0.14) | 48.18 (3.61) | 5 | 5.36 (0.19) | 142.06 (4.69) | 5 |
| WIN55,212‐2 | 7.82 (0.11) | 51.29 (2.83) | 5 | 5.93 (0.11) | 173.03 (3.28) | 5 |
| 2‐AG | 6.99 (0.05) | 55.39 (2.48) | 5 | 5.20 (0.16) | 192.31 (6.14) | 5 |
| THC | 7.74 (0.17) | 59.97 (3.50) | 5 | Not Measurable | Not Measurable | 5 |
| BAY | 7.25 (0.03) | 62.93 (3.09) | 5 | Not Measureable | Not Measureable | 5 |
| pplss‐3HA‐hCB1 HEK | ||||||
|---|---|---|---|---|---|---|
| ‐PTX | +PTX | |||||
| pEC50 (M) (± SEM) | EMAX (% of FSK) (± SEM) | n | pEC50 (M) (± SEM) | EMAX (% of FSK) (± SEM) | n | |
| CP55,940 | 7.42 (0.07) | 230.00 (12.23) | 5 | 7.93 (0.11) | 288.66 (8.29) | 5 |
| AEA | 5.79 (0.14) | 183.33 (7.03) | 5 | 6.24 (0.10) | 287.96 (11.25) | 5 |
| WIN55,212‐2 | 6.169 (0.06) | 341.98 (12.69) | 5 | 6.82 (0.07) | 331.22 (7.22) | 5 |
| 2‐AG | 5.41 (0.08) | 326.82 (13.46) | 5 | 5.99 (0.06) | 327.64 (17.94) | 5 |
| THC | Not Measurable | Not Measurable | 5 | 6.78 (0.06) | 184.59 (5.66) | 5 |
| BAY | Not Measureable | Not Measureable | 5 | 6.20 (0.17) | 186.17 (12.08) | 5 |