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. 2017 Jun 21;174(15):2457–2470. doi: 10.1111/bph.13855

Figure 5.

Figure 5

Bouchardatine reduces fat mass associated with the browning in WAT. (A) Representative images of H&E staining in epididymal WAT after 5 weeks of treatment with Bou. Original magnification, 400×. Scale bar, 400 μm. (B) Effects on the protein levels of SIRT1, LKB1 and AMPK. (C) Effects on the expression levels of fatty acid synthesis‐related proteins: FAS, ACC, SCD‐1 and SREBP‐1c. (D) Effects on the ratio of mtDNA/nDNA. (E) Effects on the expression of proteins related to the browning. (F) Effects on the levels of mRNA and protein of UCP1. * P < 0.05 compared with CH group; #P < 0.05 compared with HF group (n = 8 mice in each group). CPT‐1b, carnitine palmitoyl transferase‐1b.