Figure 5.

PA‐6 plasma concentrations in AF goats and cAVB dogs. (A) PA‐6 plasma concentrations (nM) in cardioverted AF goats (n = 5) following PA‐6 infusion (0–10 min bolus (2.5 mg·kg⁻¹·10 min⁻¹, dark grey bar), 10–60 min maintenance (0.04 mg·kg⁻¹·min⁻¹, light grey bar), 60–90 min (washout)). (B) PA‐6 plasma concentrations in SR (n = 2) and cAVB dogs (n = 2) following a low dose [0–10 min (0.5 mg·kg⁻¹·10 min⁻¹, light grey bar)] and a high dose (30–40 min 2.5 mg·kg⁻¹·10 min⁻¹, dark grey bar) bolus. Washout between 10–30 and 40–60 min respectively.