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. 2017 Jul 10;10:3353–3362. doi: 10.2147/OTT.S137726

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© 2017 Chen et al. This work is published and licensed by Dove Medical Press Limited

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TINCR was a target of miR-375 in GC cells.

Notes: (A) miR-375-binding sites on TINCR predicted by online soft RNAhybrid. (B) Relative expression of TINCR after transfecting miR-375 mimic into HGC-27 and SNU-1 cells was analyzed by using real-time PCR assays and normalized to GAPDH expression. (C and D) Luciferase activity of the indicated group in HGC-27 and SNU-1 cells by transfected miR-375 mimic + pmirGLO vector, miR-375 mimic + pmirGLO-TINCR-wt, or miR-375 mimic + pmirGLO-TINCR-mut. Statistically significant differences are indicated: *P<0.05; Student’s t-test. The experiment was repeated at least three times.

Abbreviations: GAPDH, glyceraldehyde-3-phosphate dehydrogenase; mut, mutant; GC, gastric cancer; PCR, polymerase chain reaction; wt, wild type.