FIGURE 1.

Contractile responses to phenylephrine (PE) and to 5-hydroxytryptamine (5-HT) in isolated mesenteric resistance artery (MRA) (A,B) and basilar artery (BA) (C,D); effects of apixaban (APX) and/or N^G-nitro-L-arginine (L-NNA, 0.1 mM). Notice the reduced vasoconstriction to PE or 5-HT in the presence of APX and in the absence of L-NNA, to block endogenous NO. (E,F) Effect of direct addition of APX (10–100 μM) to preparations pre-constricted by 1 μM. PE comparison to the effect of corresponding volumes of vehicle (5–50 μL DMSO). Data are the mean ± SEM of 8–12 independent measurements. ^∗P < 0.01 versus Control. Two-way ANOVA.