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Dilating responses to acetylcholine (ACh) and to sodium nitroprusside (SNP) in isolated MRA (A,B) and BA (C,D); effects of apixaban (APX). MRA was pre-constricted with 1 μM phenylephrine, BA was pre-constricted with 1 μM 5-hydroxytryptamine. The vasodilatation to exogenous NO, from the NO-donor SNP was assessed in the presence of NG-nitro-L-arginine (L-NNA, 0.1 mM), to block endogenous NO. Data are the mean ± SEM of 8–12 independent measurements.
