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Relaxing responses to the PAR-2 agonist SLIGRL in isolated MRA; effects of apixaban (APX). The vasodilatation to SLIGRL was assessed in intact arteries, in the absence (A) or in the presence (B) of NG-nitro-L-arginine (L-NNA, 0.1 mM), to block endogenous NO, or in endothelium-denuded arteries (C). MRA was pre-constricted with 1 μM phenylephrine. Data are the mean ± SEM of 8–12 independent measurements. ∗P < 0.01 versus Control. Two-way ANOVA.
