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. 2017 Jul 18;10:225. doi: 10.3389/fnmol.2017.00225

FIGURE 1.

FIGURE 1

DNA methylation patterns in PD at the promoter region of the SNCA gene. (Upper) The promoter region and 5′ end of the SNCA gene containing the core promoter and the two first exons of SNCA (Exon 1 and Exon 2) are depicted. Exon 2 contains the ATG start codon of the open reading frame (ORF). Upstream of the promoter the location of the polymorphic microsatellite sequence Rep1 is shown. Below the scheme of the SNCA gene the CpG-rich region is depicted as an CpG island (CGI). Positions of regulatory sequences (promoter and CGIs), as well as exons and introns are given at the top in reference to the ATG start codon. (Lower) Regulatory sequences and intronic regions analyzed in various studies (see text for more detail) are depicted as boxes. The references are given on the left, and the DNA methylation status and source of PD samples on the right.