Table 1.

DNA methylation status of PD associated genes.

Gene	Alias	Location	DNA methylation	Reference
PAD2	Peptidyl arginine deiminase 2	1p36.13	No difference	Mastronardi et al., 2007
ATP13A2	PARK9	1p36.13	No difference	Behrens et al., 2010
DJ-1	PARK7	1p36.23	No methylation	Tan Y. et al., 2016
NPAS2	Neuronal PAS2	2q11.2	Hypomethylation	Lin et al., 2012
UCHL1	Ubiquitin C-terminal hydrolase L1	4p13	No difference	Barrachina and Ferrer, 2009
PGC1-α	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	4p15.2	Hypermethylation	Su et al., 2015
TNF-α	Tumor necrosis factor-alpha	6p21.33	No difference	Pieper et al., 2008
PARK2	Parkinson juvenile disease protein 2, Parkin	6q26	No difference	Cai et al., 2011
			No difference	De Mena et al., 2013
CYP2E1	Cytochrome P450-J	10q26.3	Hypomethylation	Kaut et al., 2012
NOS2	Nitric oxide synthase 2	17q11.2	Hypomethylation	Searles Nielsen et al., 2015
MAPT	Microtubule associated protein Tau	17q21.31	Differential methylation	Coupland et al., 2014
FANCC/TNKS2	Fanconi anemia group C protein/tankyrase 2	9q22.32/10q23.32	Differential methylation	Moore et al., 2014
PARK16/GPNMB/STX1B	PARK16/glycoprotein Nmb/syntaxin 1B	1q32/7p15.3/16p11.2	Differential methylation	International Parkinson’s Disease Genomics Consortium [IPDGC], and Wellcome Trust Case Control Consortium 2 [WTCCC2]
Genome-wide	Top 30 differentially methylated genes: KCTD5, VAV2, MOG, TRI M10, HLA-DQA1, ARHGEF10, GFPT 2, HLA-DRB5, TMEM9, MRI 1, MAPT, HLA-DRB6, LASS3, GSTTP 2, GSTTP. DNAJA3, JAKMIP 3, FRK, LRR C27, DMBX1, LGALS7, FOXK1, APBA1, MAGI2, SLC25A24, GSTT 1, MYOM2, MIR886, TUBA3E, TMCO3		Hypermethylation Hypomethylation	Masliah et al., 2013

From left to right: Listed are genes, gene aliases, genomic locations (according to the latest GRCh38/hg38 assembly of the human genome available at the UCSC genome browser), DNA methylation status in PD and references.