Table 2.
Multivariate Cox regression analyses in the training and validation cohort.
| Variables | TTR | OS | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| TRAINING COHORT | ||||
| AFP, ng/ml (>400 vs. ≤400) | 0.832 (0.488–1.416) | 0.497 | 0.390 (0.171–0.892) | 0.026 |
| No. of tumors, (multiple vs. single) | 0.769 (0.414–1.425) | 0.403 | 0.979 (0.434–2.205) | 0.958 |
| Tumor size, cm (>5 vs. ≤5) | 0.781 (0.461–1.326) | 0.361 | 1.115 (0.564–2.204) | 0.754 |
| Tumor encapsulation, (none vs. complete) | 0.893 (0.568–1.404) | 0.623 | 1.089 (0.597–1.984) | 0.781 |
| Satellite lesion, (yes vs. no) | 1.167 (0.569–2.395) | 0.673 | 1.754 (0.692–4.444) | 0.236 |
| Vascular invasion, (yes vs. no) | 0.987 (0.598–1.631) | 0.961 | 0.864 (0.448–1.665) | 0.662 |
| Tumor differentiation, (III-IV vs. I-II) | 1.072 (0.673–1.706) | 0.771 | 1.416 (0.770–2.605) | 0.264 |
| Child-Pugh score, (A vs. B) | 1.777 (0.783–4.033) | 0.169 | 2.248 (0.848–5.961) | 0.103 |
| BCLC stage, (0+A vs. B+C) | 0.593 (0.323–1.090) | 0.092 | 0.354 (0.147–0.853) | 0.021 |
| SHI (>2.84 vs. ≤2.84) | 2.969 (1.579–5.581) | 0.001 | 2.824 (1.248–6.388) | 0.013 |
| VALIDATION COHORT | ||||
| AFP, ng/ml (>400 vs. ≤400) | 1.610 (0.916–2.831) | 0.098 | 1.429 (0.683–2.989) | 0.343 |
| No. of tumors, (multiple vs. single) | 0.883 (0.415–1.875) | 0.745 | 0.820 (0.308–2.186) | 0.692 |
| Tumor size, cm (>5 vs. ≤5) | 0.951 (0.473–1.915) | 0.889 | 0.873 (0.354–2.154) | 0.768 |
| Tumor encapsulation, (none vs. complete) | 0.650 (0.373–1.132) | 0.128 | 2.264 (1.087–4.718) | 0.029 |
| Satellite lesion, (yes vs. no) | 1.244 (0.551–2.828) | 0.599 | 1.348 (0.478–3.802) | 0.572 |
| Vascular invasion, (yes vs. no) | 0.800 (0.434–1.475) | 0.475 | 0.469 (0.206–1.069) | 0.072 |
| Tumor differentiation, (III–IV vs. I–II) | 1.051 (0.605–1.825) | 0.860 | 0.812 (0.388–1.696) | 0.579 |
| Child-Pugh score, (A vs. B) | 2.691 (0.551–2.828) | 0.033 | 3.831 (1.164–12.602) | 0.027 |
| BCLC stage, (0+A vs. B+C) | 1.459 (0.434–1.475) | 0.356 | 2.268 (0.793–6.490) | 0.127 |
| SHI, (>2.84 vs. ≤2.84) | 3.982 (1.806–8.783) | 0.001 | 4.417 (1.690–11.542) | 0.002 |
TTR, Time to recurrence; OS, Overall survival; HR, hazard ratio; CI, confidence interval; AFP, α-fetoprotein; BCLC, Barcelona Clinic Liver Cancer; SHI, systemic hepatic-damage index. Bold value represents significant (P < 0.05).