Table 1.

Current treatment options for RiED

Treatments	Benefits	Limitations
PDE5-Is	1.Easy to use 2.Safe for many patients	1.Expensive 2.Numerous side effects 3.Contraindicated with nitrate medications 4.Ineffective for severe RiED or a history of pelvic surgery
Vacuum devices	1.One-time purchase 2.Works well in patients with diabetic and psychogenic ED 3.Few known side effects	1.Should not be used with a significant congenital bleeding disorder or priapism 2.Difficult to use in obese men with increased lower abdomen fat 3.May interrupt intercourse 4.Requires proper practice to use correctly 5.Erection may not be firm enough for proper sexual activity
Penile injections	1.Can be used 5-15 minutes before intercourse 2.High bioavailability 3.High success rate	1.Injection requires manual dexterity and ability to perform self-injection 2.Mild to moderate pain after injection 3.Intracavernous injection carries the increased risk of priapism 4.High rate for discontinuation because of side effects
Penile prostheses	1.High success rates 2.For patients when PDE5-Is are contraindicated or ineffective	1.Invasive 2.Higher rate of complication in patients with obesity and high blood pressure 3.Uncontrolled postsurgery bleeding, infection, and scar tissue formation that may require removal 4.Disruption of erection reflex 5.Decreased erection duration 6.Irreversible treatment
Penile suppositories	1.Fast onset	1.Expensive 2.Ineffective in many patients 3.Can cause penile pain 4.Wears off quickly
Natural supplements	1.Inexpensive 2.Readily available	1.No definitive improvement in erections 2.May have contraindications with other medications 3.May contain unknown quantities of potent ingredients

ED, erectile dysfunction; PDE5-Is, phosphodiesterase type 5 inhibitors; RiED, radiation-induced erectile dysfunction.