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. 2017 Jul 17;7:5525. doi: 10.1038/s41598-017-05876-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Heatmap of fold changes (Log₂) in gene expression levels between vectors encoding the tested factors and the AdCMV control vector. (B) Heatmap of fold changed (Log₂) of the angiogenesis associated genes identified in the gene ontology analysis. (C and D). Gene ontology analysis using the Ingenuity Pathway Analysis: The top 3 most significantly enriched physiological functions are presented. (E) The genes differentially expressed between VEGF-A₁₆₅ and VEGF-A₁₀₉. F. qRT-PCR analysis of the expression of NR4A1, RCAN1 and STC1 in human dermal blood endothelial cells. The data is presented as mean ± SEM. **P < 0.01, ***P < 0.001.