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. 2017 Jul 17;7:5546. doi: 10.1038/s41598-017-05999-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ventricle model simulations: Sarcomere lengths in different finite elements at the end of the diastolic phase (upper part) and active tension at peak (lower part, at 0.1 s after the beginning of the systolic phase). Two preloads are shown, at 5 and 15 mmHg (left and right, respectively). The tension is higher at 15 mmHg because of the effects of titin on the mechanosensing mechanism.